ArticleJournal of clinical microbiology2012
mecA-positive Staphylococcus aureus with low-level oxacillin MIC in Taiwan.
Article in Journal of clinical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Virulence determinants and multidrug resistance profiles of biofilm-forming Staphylococcus aureus from healthy orthopedic surgical personnel.Antonie van Leeuwenhoek · 2026Article
- Oxacillin-susceptible methicillin-resistantJournal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2025Article
- Current status of the distribution and antimicrobial resistance of Staphylococcus felis isolates from feline patients in Japan.The Journal of veterinary medical science · 2025Article
- Mec-A Positive Methicillin-SusceptibleReports of biochemistry & molecular biology · 2024Article
- Rapid Direct Identification of Microbial Pathogens and Antimicrobial Resistance Genes in Positive Blood Cultures Using a Fully Automated Multiplex PCR Assay.Journal of Korean medical science · 2024Article
- Comparative Analysis of Two Commercial Automated Systems with Agar Dilution for Oxacillin Susceptibility and Their Association with Genotypes of InvasiveInfection and drug resistance · 2024Article
- Antibiotic Resistance Profile and Biofilm Production ofPharmaceuticals (Basel, Switzerland) · 2021Article
- Antimicrobial resistance and genotyping of Staphylococcus aureus obtained from food animals in Sichuan Province, China.BMC veterinary research · 2021Article
- First Report of Oxacillin SusceptibleInfection and drug resistance · 2021Article
- Distribution and antibiotic-resistance of differentJournal of oral microbiology · 2021Article
- Presence of egc-positive major clones ST 45, 30 and 22 among methicillin-resistant and methicillin-susceptible oral Staphylococcus aureus strains.Scientific reports · 2020Article
- Identification and characterization of mutations responsible for the β-lactam resistance in oxacillin-susceptible mecA-positive Staphylococcus aureus.Scientific reports · 2020Article
- Antimicrobial Resistance in ESKAPE Pathogens.Clinical microbiology reviews · 2020Review
- Specific staphylococcal cassette chromosome mec (SCCmec) types and clonal complexes are associated with low-level amoxicillin/clavulanic acid and cefalotin resistance in methicillin-resistant Staphylococcus pseudintermedius.The Journal of antimicrobial chemotherapy · 2020Article
- nanoMLST: accurate multilocus sequence typing using Oxford Nanopore Technologies MinION with a dual-barcode approach to multiplex large numbers of samples.Microbial genomics · 2020Article
- Control of Methicillin-ResistantFrontiers in microbiology · 2020Article
- Emergence of Oxacillin Resistance in Stealth Methicillin-ResistantAntimicrobial agents and chemotherapy · 2019Article
- Indocyanine Green-Mediated Photodynamic Therapy Reduces Methicillin-ResistantJournal of clinical medicine · 2019Article
- Dissemination Of t437-SCCInfection and drug resistance · 2019Article
- Membrane Vesicles Are the Dominant Structural Components of Ceftazidime-Induced Biofilm Formation in an Oxacillin-Sensitive MRSA.Frontiers in microbiology · 2019Article
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Authors and funding
9 authors.
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Abstract
Although the presence of mecA is the genotypic determinant of methicillin-resistant Staphylococcus aureus (MRSA), certain MRSA strains, especially community-associated MRSA (C-MRSA), can display an oxacillin MIC in the Clinical and Laboratory Standards Institute susceptible breakpoint range (≤ 2 μg/ml). Among 91 and 180 isolates thought to be methicillin-susceptible S. aureus (MSSA) with oxacillin MICs of 2 and 1 μg/ml as determined by the Sensititre broth microdilution test initially, 52 (57.1%) and 6 (3.3%), respectively, were mecA positive. These mecA-positive low-oxacillin-MIC isolates belong to the dominant Taiwan C-MRSA clone (clonal complex [CC] 59), 56 of which carried SCCmec type V and were pvl positive, and 43 of which belonged to spa CC t437. All 271 isolates were retested by Sensititre, as well as by Vitek II and disk diffusion (DD). Based on the oxacillin results, the sensitivities of the Sensititre, Vitek II, and DD methods were 48.3% (28/58), 46.6% (27/58), and 89.6% (52/58), respectively. Although cefoxitin was better at detecting these isolates, 12.1, 10.4, and 5.2% of these isolates were still misidentified as MSSA by Sensititre, Vitek II, and DD, respectively. These results highlight the difficulty in the accurate identification of MRSA with borderline oxacillin MICs in the CC59:SCCmec V clone, which likely has contributed to its spread in the health care and community settings. Since this clone has now been detected in other countries, and since other C-MRSA lineages have also been found to have low-level β-lactam resistance, the findings of the present study may be relevant to other regions. Further studies are warranted to determine the extent and clinical impact of such misidentification.
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