ArticleProceedings. Biological sciences2012
Conserved properties of Drosophila and human spermatozoal mRNA repertoires.
Article in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- A catalog of mRNAs transferred from males to females during mating in Drosophila arizonae and D. mojavensis.PloS one · 2026Article
- Sperm epigenetics and sperm RNAs as drivers of male infertility: truth or myth?Molecular and cellular biochemistry · 2025Review
- Silent cells? Potential for context-dependent gene expression in mature sperm.Proceedings. Biological sciences · 2025Review
- Females translate male mRNA transferred during mating.iScience · 2024Article
- Selection and geography shape male reproductive tract transcriptomes in Drosophila melanogaster.Genetics · 2023Article
- Some sexual consequences of being a plant.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Rapid Genomic Evolution Drives the Diversification of Male Reproductive Genes in Dung Beetles.Genome biology and evolution · 2021Article
- Differences in Postmating Transcriptional Responses between Conspecific and Heterospecific Matings in Drosophila.Molecular biology and evolution · 2021Article
- Insights into the Mechanism of Bovine Spermiogenesis Based on Comparative Transcriptomic Studies.Animals : an open access journal from MDPI · 2021Article
- Post-ejaculation thermal stress causes changes to the RNA profile of sperm in an external fertilizer.Proceedings. Biological sciences · 2020Article
- Evolved Differences inGenetics · 2020Article
- Single-cell sperm transcriptomes and variants from fathers of children with and without autism spectrum disorder.NPJ genomic medicine · 2020Article
- Article
- Specialized eRpL22 paralogue-specific ribosomes regulate specific mRNA translation in spermatogenesis inMolecular biology of the cell · 2019Article
- Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques.The world journal of men's health · 2019Review
- Proteins, Transcripts, and Genetic Architecture of Seminal Fluid and Sperm in the MosquitoMolecular & cellular proteomics : MCP · 2019Article
- Article
- Is transcription in sperm stationary or dynamic?The Journal of reproduction and development · 2017Review
- Comparative Sperm Proteomics in Mouse Species with Divergent Mating Systems.Molecular biology and evolution · 2017Article
- Genetic variation for resistance to high temperature stress of mature sperm - a study in Drosophila.PloS one · 2017Article
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Authors and funding
7 authors.
Funding
Abstract
It is now well established that mature mammalian spermatozoa carry a population of mRNA molecules, at least some of which are transferred to the oocyte at fertilization, however, their function remains largely unclear. To shed light on the evolutionary conservation of this feature of sperm biology, we analysed highly purified populations of mature sperm from the fruitfly, Drosophila melanogaster. As with mammalian sperm, we found a consistently enriched population of mRNA molecules that are unlikely to be derived from contaminating somatic cells or immature sperm. Using tagged transcripts for three of the spermatozoal mRNAs, we demonstrate that they are transferred to the oocyte at fertilization and can be detected before, and at least until, the onset of zygotic gene expression. We find a remarkable conservation in the functional annotations associated with fly and human spermatozoal mRNAs, in particular, a highly significant enrichment for transcripts encoding ribosomal proteins (RPs). The substantial functional coherence of spermatozoal transcripts in humans and the fly opens the possibility of using the power of Drosophila genetics to address the function of this enigmatic class of molecules in sperm and in the oocyte following fertilization.
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