ReviewNutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition2012
Of microbes and meals: the health consequences of dietary endotoxemia.
Review in Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 96 citations in OpenAlex.
- Trial
- Marital distress, depression, and a leaky gut: Translocation of bacterial endotoxin as a pathway to inflammation.Psychoneuroendocrinology · 2018Trial
- Trial
- Postprandial effects of polydextrose on satiety hormone responses and subjective feelings of appetite in obese participants.Nutrition journal · 2015Trial
- Effects of different complementary feeding regimens on iron status and enteric microbiota in breastfed infants.The Journal of pediatrics · 2013Trial
- Dissection of MAPK and NF-κB p65 signaling dynamics underlying LPS tolerance in macrophages at the single-cell level.Biotechnology reports (Amsterdam, Netherlands) · 2026Article
- Genetic evidence for causal roles of circulating proteins on breast cancer susceptibility.iScience · 2026Article
- The Relationship Between Dietary Inflammatory Index and Intermediate-to-High-Risk Cardiovascular-Kidney-Metabolic Syndrome and All-Cause Mortality: The National Health and Nutrition Examination Survey 1999-2018: A Cross-Sectional and Prospective Cohort Study.Health science reports · 2026Article
- Limitations and safety aspects related to the use of bacteriophages in food production.FEMS microbiology reviews · 2026Article
- Article
- TreeKernel: interpretable kernel machine tests for interactions between -omics and clinical predictors with applications to metabolomics and COPD phenotypes.BMC bioinformatics · 2023Article
- mInd the gAP: Intestinal Alkaline Phosphatase Puts the Breaks on Atherosclerosis.Circulation research · 2021Article
- Association between yogurt consumption and plasma soluble CD14 in two prospective cohorts of US adults.European journal of nutrition · 2021Article
- tidyMicro: a pipeline for microbiome data analysis and visualization using the tidyverse in R.BMC bioinformatics · 2021Article
- Obese Adolescents With PCOS Have Altered Biodiversity and Relative Abundance in Gastrointestinal Microbiota.The Journal of clinical endocrinology and metabolism · 2020Article
- Gut microbial dysbiosis in individuals with Sjögren's syndrome.Microbial cell factories · 2020Article
- Serum lipopolysaccharides predict advanced liver disease in the general population.JHEP reports : innovation in hepatology · 2019Article
- Composition and richness of the serum microbiome differ by age and link to systemic inflammation.GeroScience · 2018Article
- Serum Zonulin and Endotoxin Levels in Exceptional Longevity versus Precocious Myocardial Infarction.Aging and disease · 2018Article
- Plasma levels of lipopolysaccharide correlate with insulin resistance in HIV patients.Diabetology & metabolic syndrome · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The human intestinal tract comprises a rich and complex microbial ecosystem. This intestinal microbota provides a large reservoir of potentially toxic molecules, including bacterial endotoxin (ie, lipopolysaccharide [LPS]). This potent inflammatory molecule is detectable in the circulation of healthy individuals, and levels transiently increase following ingestion of energy-rich meals. Chronic exposure to circulating endotoxin has been associated with obesity, diabetes, and cardiovascular disease. Western-style meals augment LPS translocation and by this mechanism may contribute to the pathogenesis of these diseases. By contrast, the gut and other organs have evolved mechanisms to detoxify endotoxin and neutralize the potentially inflammatory qualities of circulating endotoxin. Of specific interest to clinicians is evidence that acute postprandial elevation of circulating endotoxin is dependent on meal composition. In this review, the authors present an overview of the biochemical and cellular mechanisms that lead to endotoxemia, with emphasis on the interplay between microbial and nutrition determinants of this condition. The link between endotoxemia, diet, and changes in the intestinal microbiota raise the possibility that dietary interventions can, at least in part, ameliorate the detrimental outcomes of endotoxemia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.