ArticleDevelopment (Cambridge, England)2012
The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- MIG-21 interacts with Wnt and Netrin signaling in gonad migration in C. elegans.PLoS genetics · 2025Article
- MIG-21 is a novel regulator of Wnt and Netrin signaling in gonad migration identified from published scRNA-seq data and functionally validated inbioRxiv : the preprint server for biology · 2025Article
- A postmeiotically bifurcated roadmap of honeybee spermatogenesis marked by phylogenetically restricted genes.PLoS genetics · 2023Article
- Lar maintains the homeostasis of the hematopoietic organ inDevelopment (Cambridge, England) · 2019Article
- Review
- Article
- Review
- Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila.Nature communications · 2016Article
- Regulation of Platelet Derived Growth Factor Signaling by Leukocyte Common Antigen-related (LAR) Protein Tyrosine Phosphatase: A Quantitative Phosphoproteomics Study.Molecular & cellular proteomics : MCP · 2016Article
- Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling.PLoS genetics · 2016Article
- Heparan sulfate regulates the number and centrosome positioning of Drosophila male germline stem cells.Molecular biology of the cell · 2016Article
- The novel tumour suppressor Madm regulates stem cell competition in the Drosophila testis.Nature communications · 2016Article
- The Nuclear Matrix Protein Megator Regulates Stem Cell Asymmetric Division through the Mitotic Checkpoint Complex in Drosophila Testes.PLoS genetics · 2015Article
- Stem cell autotomy and niche interaction in different systems.World journal of stem cells · 2015Review
- Coordinate regulation of stem cell competition by Slit-Robo and JAK-STAT signaling in the Drosophila testis.PLoS genetics · 2014Article
- Modulating the stem cell niche for tissue regeneration.Nature biotechnology · 2014Review
- The actin-binding protein profilin is required for germline stem cell maintenance and germ cell enclosure by somatic cyst cells.Development (Cambridge, England) · 2014Article
- The polyubiquitin gene Ubi-p63E is essential for male meiotic cell cycle progression and germ cell differentiation in Drosophila.Development (Cambridge, England) · 2013Article
- Adhesion in the stem cell niche: biological roles and regulation.Development (Cambridge, England) · 2013Review
- Genetic, immunofluorescence labeling, and in situ hybridization techniques in identification of stem cells in male and female germline niches.Methods in molecular biology (Clifton, N.J.) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The stem cell niche provides a supportive microenvironment to maintain adult stem cells in their undifferentiated state. Adhesion between adult stem cells and niche cells or the local basement membrane ensures retention of stem cells in the niche environment. Drosophila male germline stem cells (GSCs) attach to somatic hub cells, a component of their niche, through E-cadherin-mediated adherens junctions, and orient their centrosomes toward these localized junctional complexes to carry out asymmetric divisions. Here we show that the transmembrane receptor tyrosine phosphatase Leukocyte-antigen-related-like (Lar), which is best known for its function in axonal migration and synapse morphogenesis in the nervous system, helps maintain GSCs at the hub by promoting E-cadherin-based adhesion between hub cells and GSCs. Lar is expressed in GSCs and early spermatogonial cells and localizes to the hub-GSC interface. Loss of Lar function resulted in a reduced number of GSCs at the hub. Lar function was required cell-autonomously in germ cells for proper localization of Adenomatous polyposis coli 2 and E-cadherin at the hub-GSC interface and for the proper orientation of centrosomes in GSCs. Ultrastructural analysis revealed that in Lar mutants the adherens junctions between hub cells and GSCs lack the characteristic dense staining seen in wild-type controls. Thus, the Lar receptor tyrosine phosphatase appears to polarize and retain GSCs through maintenance of localized E-cadherin-based adherens junctions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.