ArticleJournal of neurophysiology2012
GABAA receptors increase excitability and conduction velocity of cerebellar parallel fiber axons.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Beyond synaptic plasticity: a summary of a linear model of the cerebellar locomotor computation.Frontiers in neural circuits · 2026Review
- Computational anatomy: the cerebellar microzone computation.Oxford open neuroscience · 2025Article
- Jiawei Suanzaoren decoction for the treatment of perimenopausal insomnia: clinical observation and experimental study.Frontiers in pharmacology · 2024Article
- Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling.Cells · 2021Review
- Article
- Direction of action of presynaptic GABAJournal of neurophysiology · 2019Article
- Antidromic Analog Signaling.Frontiers in cellular neuroscience · 2019Review
- Axonal GABAThe Journal of physiology · 2017Article
- Axonal Conduction Delays, Brain State, and Corticogeniculate Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon.Nature communications · 2016Article
- Biphasic modulation of parallel fibre synaptic transmission by co-activation of presynaptic GABAA and GABAB receptors in mice.The Journal of physiology · 2016Article
- Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Excitation by Axon Terminal GABA Spillover in a Sound Localization Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Signal Propagation between Neuronal Populations Controlled by Micropatterning.Frontiers in bioengineering and biotechnology · 2016Article
- Impact of single-site axonal GABAergic synaptic events on cerebellar interneuron activity.The Journal of general physiology · 2015Article
- Mini-Review: Effects of Ethanol on GABAA Receptor-Mediated Neurotransmission in the Cerebellar Cortex--Recent Advances.Cerebellum (London, England) · 2015Review
- An excitatory GABA loop operating in vivo.Frontiers in cellular neuroscience · 2015Article
- The contribution of extrasynaptic signaling to cerebellar information processing.Cerebellum (London, England) · 2014Review
- Synthesis and biological evaluation of bis-CNB-GABA, a photoactivatable neurotransmitter with low receptor interference and chemical two-photon uncaging properties.Journal of the American Chemical Society · 2014Article
- Activation of axonal receptors by GABA spillover increases somatic firing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In the adult mammalian brain, GABA(A) receptors (GABA(A)Rs) are responsible for the predominant forms of synaptic inhibition, but these receptors can excite neurons when the chloride equilibrium potential (E(Cl)) is depolarized. In many mature neurons, GABA(A)Rs are found on presynaptic terminals where they exert depolarizing effects. To understand whether excitatory GABA action affects axonal function, we used transverse cerebellar slices to measure the effects of photolysis of caged GABA on the initiation and propagation of compound parallel fiber (PF) action potentials (APs). Photolysis of caged GABA increased the amplitude and conduction velocity of PF APs; GABA reuptake blockers and a positive modulator of GABA(A)Rs enhanced these effects. In contrast, a modulator selective for δ-subunit-containing GABA(A)Rs did not enhance these effects and responsiveness remained in δ(-/-) mice, arguing that δ-subunit-containing GABA(A)Rs are not required. Synaptically released GABA also increased PF excitability, indicating that the mechanism is engaged by physiological signals. A Hodgkin-Huxley-style compartmental model of the PF axon and granule cell body was constructed, and this model recapitulated the GABA-dependent decrease in AP threshold and the increase in conduction velocity, features that were sensitive to E(Cl) and to the voltage dependence of sodium channel inactivation. The model also predicts that axonal GABA(A)Rs could affect orthodromic spike initiation. We conclude that GABA acting on cerebellar PFs facilitates both spike generation and propagation, allowing axons of granule cells to passively integrate signals from inhibitory interneurons and influence information flow in the input layer to the cerebellar cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.