ArticleJournal of neurophysiology2012
Diverse levels of an inwardly rectifying potassium conductance generate heterogeneous neuronal behavior in a population of dorsal cochlear nucleus pyramidal neurons.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Impacts of Kv3.1 Channels on Action Potentials in Fusiform Neurons From the Dorsal Cochlear Nucleus of Mice Before and After Hearing Onset.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Subthreshold Kir and IBiological research · 2026Article
- A comprehensive review of HCN channel expression and IJournal of neurophysiology · 2025Review
- Calcium-Sensitive Subthreshold Oscillations and Electrical Coupling in Principal Cells of Mouse Dorsal Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Sparsely Distributed, Pre-synaptic Kv3 KFrontiers in cellular neuroscience · 2021Article
- Ionic current correlations are ubiquitous across phyla.Scientific reports · 2019Article
- Classification of neurons in the adult mouse cochlear nucleus: Linear discriminant analysis.PloS one · 2019Article
- AThe Journal of general physiology · 2018Article
- Non-Decaying postsynaptics potentials and delayed spikes in hippocampal pyramidal neurons generated by a zero slope conductance created by the persistent NaChannels (Austin, Tex.) · 2018Article
- A Negative Slope Conductance of the Persistent Sodium Current Prolongs Subthreshold Depolarizations.Biophysical journal · 2017Article
- The role of negative conductances in neuronal subthreshold properties and synaptic integration.Biophysical reviews · 2017Review
- Dynamic compensation mechanism gives rise to period and duty-cycle level sets in oscillatory neuronal models.Journal of neurophysiology · 2016Article
- Auditory Golgi cells are interconnected predominantly by electrical synapses.Journal of neurophysiology · 2016Article
- Article
- Tonic zinc inhibits spontaneous firing in dorsal cochlear nucleus principal neurons by enhancing glycinergic neurotransmission.Neurobiology of disease · 2015Article
- Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus.eLife · 2015Article
- Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Serotonergic regulation of excitability of principal cells of the dorsal cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Synaptic mechanisms for generating temporal diversity of auditory representation in the dorsal cochlear nucleus.Journal of neurophysiology · 2015Article
- Control of Phasic Firing by a Background Leak Current in Avian Forebrain Auditory Neurons.Frontiers in cellular neuroscience · 2015Article
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4 authors.
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Abstract
Homeostatic mechanisms maintain homogeneous neuronal behavior among neurons that exhibit substantial variability in the expression levels of their ionic conductances. In contrast, the mechanisms, which generate heterogeneous neuronal behavior across a neuronal population, remain poorly understood. We addressed this problem in the dorsal cochlear nucleus, where principal neurons exist in two qualitatively distinct states: spontaneously active or not spontaneously active. Our studies reveal that distinct activity states are generated by the differential levels of a Ba(2+)-sensitive, inwardly rectifying potassium conductance (K(ir)). Variability in K(ir) maximal conductance causes variations in the resting membrane potential (RMP). Low K(ir) conductance depolarizes RMP to voltages above the threshold for activating subthreshold-persistent sodium channels (Na(p)). Once Na(p) channels are activated, the RMP becomes unstable, and spontaneous firing is triggered. Our results provide a biophysical mechanism for generating neural heterogeneity, which may play a role in the encoding of sensory information.
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