Evidence map›Paper›PMID 22378035›Full record

ArticleAmerican journal of hypertension2012

Masked hypertension and prehypertension: diagnostic overlap and interrelationships with left ventricular mass: the Masked Hypertension Study.

Daichi Shimbo, Jonathan D Newman, Joseph E Schwartz

Abstract readComparative Study
In one paragraph

Article in American journal of hypertension, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Blood Pressure and Heart Rate Response to Orthostasis in Somali Americans.Journal of racial and ethnic health disparities · 2026
    Article
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  8. Review
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  15. Clinical applications for out-of-office blood pressure monitoring.Therapeutic advances in chronic disease · 2020
    Review
  16. Masked hypertensives: A disguised arterial stiffness population.Journal of clinical hypertension (Greenwich, Conn.) · 2019
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Daichi ShimboDepartment of Medicine, Columbia University Medical Center, New York, New York, USA. ds2231@columbia.edu
Jonathan D Newman
Joseph E Schwartz

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
WORKSITE BLOOD PRESSURE STUDYP01HL047540 · NHLBI · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI SCHWARTZ, JOSEPH E · 1993 to 2014
$27.7M
World Trade Center Worker and Volunteer Medical Screening ProgramM01RR010710 · NCRR · STATE UNIVERSITY NEW YORK STONY BROOK · PI BAHOU, WADIE F · 1998 to 2009
$17.6M
POSTDOCTORAL TRAINING IN CARDIOVASCULAR DISEASET32HL007854 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Marwah Abdalla, Michael Argenziano · 1996 to 2026
$14.7M
MIND-BODY-BEHAVIORAL MED CLINICAL TRIALS INFRASTRUCTURER24HL076857 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN A · 2004 to 2008
$3.5M
NCRR NIH HHS M01 RR010710NCRR NIH HHS MO1-RR10710NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1-RR024156NHLBI NIH HHS P01 HL047540NHLBI NIH HHS P01-HL047540NHLBI NIH HHS R24 HL076857NHLBI NIH HHS R24-HL076857NHLBI NIH HHS T32 HL007854NHLBI NIH HHS T32-HL007854-15
6 · The paper itself

Abstract

backgroundMasked hypertension (MHT) and prehypertension (PHT) are both associated with an increase in cardiovascular disease (CVD) risk, relative to sustained normotension. This study examined the diagnostic overlap between MHT and PHT, and their interrelationships with left ventricular (LV) mass index (LVMI), a marker of cardiovascular end-organ damage.

methodsA research nurse performed three manual clinic blood pressure (CBP) measurements on three occasions over a 3-week period (total of nine readings, which were averaged) in 813 participants without treated hypertension from the Masked Hypertension Study, an ongoing worksite-based, population study. Twenty-four-hour ambulatory blood pressure (ABP) was assessed by using a SpaceLabs 90207 monitor. LVMI was determined by echocardiography in 784 (96.4%) participants.

resultsOf the 813 participants, 769 (94.6%) had normal CBP levels (<140/90 mm Hg). One hundred and seventeen (15.2%) participants with normal CBP had MHT (normal CBP and mean awake ABP ≥135/85 mm Hg) and 287 (37.3%) had PHT (mean CBP 120-139/80-89 mm Hg). 83.8% of MHT participants had PHT and 34.1% of PHT participants had MHT. MHT was infrequent (3.9%) when CBP was optimal (<120/80 mm Hg). After adjusting for age, gender, body mass index (BMI), race/ethnicity, history of high cholesterol, history of diabetes, current smoking, family history of hypertension, and physical activity, compared with optimal CBP with MHT participants, LVMI was significantly greater in PHT without MHT participants and in PHT with MHT participants.

conclusionsIn this community sample, there was substantial diagnostic overlap between MHT and PHT. The diagnosis of MHT using an ABP monitor may not be warranted for individuals with optimal CBP.

Indexed as

AdultBlood PressureBlood Pressure Monitoring, AmbulatoryDiagnosis, DifferentialEchocardiographyFemaleHeart VentriclesHumansMaleMasked HypertensionMiddle AgedPrehypertensionRetrospective Studies

Identifiers

PMID22378035
PMCPMC3668422

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.