Evidence map›Paper›PMID 22377633›Full record

ArticleGenetics2012

Remarkably high rate of DNA amplification promoted by the mating-type switching mechanism in Schizosaccharomyces pombe.

Chuanhe Yu, Michael J Bonaduce, Amar J S Klar

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Chuanhe YuDevelopmental Genetics Section, Gene Regulation and Chromosome Biology Laboratory, National Institutes of Health, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
Michael J Bonaduce
Amar J S Klar
National Institutes of Health · USNational Cancer Institute · US

Funding

Studies on SilencingZIABC010381 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KLAR, AMAR J · 2009 to 2016
$3.6M
Studies on mat1 ImprintingZIABC010385 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KLAR, AMAR J · 2009 to 2016
$3.6M
Intramural NIH HHS
6 · The paper itself

Abstract

A novel mating-type switching-defective mutant showed a highly unstable rearrangement at the mating-type locus (mat1) in fission yeast. The mutation resulted from local amplification of a 134-bp DNA fragment by the mat1-switching phenomenon. We speculate that the rolling-circle-like replication and homologous recombination might be the general mechanisms for local genome region expansion.

Indexed as

Gene AmplificationMutation RateAllelesBase SequenceDNA, FungalGenes, Mating Type, FungalMolecular Sequence DataPhenotypeSchizosaccharomycesSchizosaccharomyces pombe ProteinsDNA, FungalSchizosaccharomyces pombe Proteins

Identifiers

PMID22377633
PMCPMC3338267
OpenAlexW2102178226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.