Evidence map›Paper›PMID 22377426›Full record

ArticleEmerging infectious diseases2012

Pathogenic potential to humans of bovine Escherichia coli O26, Scotland.

Margo E Chase-Topping, Tracy Rosser, Lesley J Allison, Emily Courcier, Judith Evans, Iain J McKendrick, Michael C Pearce, Ian Handel, Alfredo Caprioli, Helge Karch and 7 more

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 43 citations in OpenAlex.

  1. An outbreak of Shiga toxin-producingEpidemiology and infection · 2026
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  8. Serogroups, subtypes and virulence factors of shiga toxin-producingGastroenterology and hepatology from bed to bench · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 4 countries.

Margo E Chase-ToppingCentre for Immunity, Infection, and Evolution, University of Edinburgh, Kings Buildings, Edinburgh EH9 3J5, UK. margo.chase@ed.ac.uk
Tracy Rosser
Lesley J Allison
Emily Courcier
Judith Evans
Iain J McKendrick
Michael C Pearce
Ian Handel
Alfredo Caprioli
Helge Karch
Mary F Hanson
Kevin G J Pollock
Mary E Locking
Mark E J Woolhouse
Louise Matthews
J Chris Low
David L Gally
Département Santé Animale · FRHealth Protection Scotland · GBBiomathematics and Statistics Scotland · GBCentre for Immunity, Infection and Evolution · GBIstituto Superiore di Sanità · ITRoslin Institute · GBScottish Agricultural Science Agency · GBTransport & Travel Research (United Kingdom) · GBUniversity of Münster · DE

Funding

Biotechnology and Biological Sciences Research CouncilWellcome Trust 095831
6 · The paper itself

Abstract

Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin-producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections. To investigate this discrepancy, we genotyped E. coli O26 isolates from cattle and humans in Scotland and continental Europe. The genetic background of some strains from Scotland was closely related to that of strains causing severe infections in Europe. Nonmetric multidimensional scaling found an association between hemolytic uremic syndrome (HUS) and multilocus sequence type 21 strains and confirmed the role of stx(2) in severe human disease. Although the prevalences of E. coli O26 and O157 on cattle farms in Scotland are equivalent, prevalence of more virulent strains is low, reducing human infection risk. However, new data on E. coli O26-associated HUS in humans highlight the need for surveillance of non-O157 enterohemorrhagic E. coli and for understanding stx(2) phage acquisition.

Indexed as

AnimalsCattleCattle DiseasesEscherichia coli InfectionsEscherichia coli O157HumansMultilocus Sequence TypingPrevalenceScotlandShiga-Toxigenic Escherichia coliShiga ToxinsVirulence FactorsShiga ToxinsVirulence Factors

Identifiers

PMID22377426
PMCPMC3309639
OpenAlexW1992564596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.