ArticleEmerging infectious diseases2012
A systematic approach for discovering novel, clinically relevant bacteria.
Article in Emerging infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Article
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- The Use of Next-Generation Sequencing in Personalized Medicine.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Microbiology ofOpen forum infectious diseases · 2024Article
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- A high throughput screening process and quick isolation of novel lignin-degrading microbes from large number of natural biomasses.Biotechnology reports (Amsterdam, Netherlands) · 2023Article
- Roles for Pathogen Interference in Influenza Vaccination, with Implications to Vaccine Effectiveness (VE) and Attribution of Influenza Deaths.Infectious disease reports · 2022Review
- Phenotypic correlates of the working dog microbiome.NPJ biofilms and microbiomes · 2022Article
- Role of Williamsia and Segniliparus in human infections with the approach taxonomy, cultivation, and identification methods.Annals of clinical microbiology and antimicrobials · 2021Review
- Pathogen identification in culture-negative cerebrospinal fluid specimens of patients with purulent meningitis using next-generation sequencing technology.International journal of clinical and experimental pathology · 2020Article
- Detection of respiratory pathogens in clinical samples using metagenomic shotgun sequencing.Journal of medical microbiology · 2019Article
- Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products.Marine drugs · 2019Review
- Diagnosing and tracing the pathogens of infantile infectious diarrhea by amplicon sequencing.Gut pathogens · 2019Article
- Article
- PaPrBaG: A machine learning approach for the detection of novel pathogens from NGS data.Scientific reports · 2017Article
- Comparison of 16S ribosomal RNA gene sequence analysis and conventional culture in the environmental survey of a hospital.Journal of pharmaceutical health care and sciences · 2017Article
- Automated Broad-Range Molecular Detection of Bacteria in Clinical Samples.Journal of clinical microbiology · 2016Article
- Nested Machine Learning Facilitates Increased Sequence Content for Large-Scale Automated High Resolution Melt Genotyping.Scientific reports · 2016Article
- A Year of Infection in the Intensive Care Unit: Prospective Whole Genome Sequencing of Bacterial Clinical Isolates Reveals Cryptic Transmissions and Novel Microbiota.PLoS genetics · 2015Article
- Potentially novel Ehrlichia species in horses, Nicaragua.Emerging infectious diseases · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sequencing of the 16S rRNA gene (16S) is a reference method for bacterial identification. Its expanded use has led to increased recognition of novel bacterial species. In most clinical laboratories, novel species are infrequently encountered, and their pathogenic potential is often difficult to assess. We reviewed partial 16S sequences from >26,000 clinical isolates, analyzed during February 2006-June 2010, and identified 673 that have <99% sequence identity with valid reference sequences and are thus possibly novel species. Of these 673 isolates, 111 may represent novel genera (<95% identity). Isolates from 95 novel taxa were recovered from multiple patients, indicating possible clinical relevance. Most repeatedly encountered novel taxa belonged to the genera Nocardia (14 novel taxa, 42 isolates) and Actinomyces (12 novel taxa, 52 isolates). This systematic approach for recognition of novel species with potential diagnostic or therapeutic relevance provides a basis for epidemiologic surveys and improvement of sequence databases and may lead to identification of new clinical entities.
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