ArticleGenome biology2012
Chromatin structural changes around satellite repeats on the female sex chromosome in Schistosoma mansoni and their possible role in sex chromosome emergence.
Article in Genome biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Schistosome W-Linked Genes Inform Temporal Dynamics of Sex Chromosome Evolution and Suggest Candidate for Sex Determination.Molecular biology and evolution · 2021Article
- Satellite-Like W-Elements: Repetitive, Transcribed, and Putative Mobile Genetic Factors with Potential Roles for Biology and Evolution of Schistosoma mansoni.Genome biology and evolution · 2021Article
- Review
- Glabralysins, Potential New β-Pore-Forming Toxin Family Members from the Schistosomiasis Vector SnailGenes · 2020Article
- Dosage Compensation throughout the Schistosoma mansoni Lifecycle: Specific Chromatin Landscape of the Z Chromosome.Genome biology and evolution · 2019Article
- Whole genome amplification and exome sequencing of archived schistosome miracidia.Parasitology · 2018Article
- Article
- Satellite DNAs are conserved and differentially transcribed among Gryllus cricket species.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Parent-of-Origin-Dependent Gene Expression in Male and Female Schistosome Parasites.Genome biology and evolution · 2018Article
- Uncovering the evolutionary history of neo-XY sex chromosomes in the grasshopper Ronderosia bergii (Orthoptera, Melanoplinae) through satellite DNA analysis.BMC evolutionary biology · 2018Article
- High-throughput analysis of the satellitome revealed enormous diversity of satellite DNAs in the neo-Y chromosome of the cricket Eneoptera surinamensis.Scientific reports · 2017Article
- (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach.Trends in parasitology · 2017Review
- Sex-Biased Transcriptome of Schistosoma mansoni: Host-Parasite Interaction, Genetic Determinants and Epigenetic Regulators Are Associated with Sexual Differentiation.PLoS neglected tropical diseases · 2016Article
- Unraveling the Sex Chromosome Heteromorphism of the Paradoxical Frog Pseudis tocantins.PloS one · 2016Article
- Contrasting the Chromosomal Organization of Repetitive DNAs in Two Gryllidae Crickets with Highly Divergent Karyotypes.PloS one · 2015Article
- The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection.PLoS neglected tropical diseases · 2015Article
- Efficient linkage mapping using exome capture and extreme QTL in schistosome parasites.BMC genomics · 2014Article
- Elucidating the molecular bases of epigenetic inheritance in non-model invertebrates: the case of the root-knot nematode Meloidogyne incognita.Frontiers in physiology · 2014Article
- Analysis of transposable elements in the genome of Asparagus officinalis from high coverage sequence data.PloS one · 2014Article
- A ZZ/ZW microchromosome system in the spiny softshell turtle, Apalone spinifera, reveals an intriguing sex chromosome conservation in Trionychidae.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Article
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9 authors.
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Abstract
backgroundIn the leuphotrochozoan parasitic platyhelminth Schistosoma mansoni, male individuals are homogametic (ZZ) whereas females are heterogametic (ZW). To elucidate the mechanisms that led to the emergence of sex chromosomes, we compared the genomic sequence and the chromatin structure of male and female individuals. As for many eukaryotes, the lower estimate for the repeat content is 40%, with an unknown proportion of domesticated repeats. We used massive sequencing to de novo assemble all repeats, and identify unambiguously Z-specific, W-specific and pseudoautosomal regions of the S. mansoni sex chromosomes.
resultsWe show that 70 to 90% of S. mansoni W and Z are pseudoautosomal. No female-specific gene could be identified. Instead, the W-specific region is composed almost entirely of 36 satellite repeat families, of which 33 were previously unknown. Transcription and chromatin status of female-specific repeats are stage-specific: for those repeats that are transcribed, transcription is restricted to the larval stages lacking sexual dimorphism. In contrast, in the sexually dimorphic adult stage of the life cycle, no transcription occurs. In addition, the euchromatic character of histone modifications around the W-specific repeats decreases during the life cycle. Recombination repression occurs in this region even if homologous sequences are present on both the Z and W chromosomes.
conclusionOur study provides for the first time evidence for the hypothesis that, at least in organisms with a ZW type of sex chromosomes, repeat-induced chromatin structure changes could indeed be the initial event in sex chromosome emergence.
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