ArticleMolecular pharmaceutics2012
Raman microscopy for noninvasive imaging of pharmaceutical nanocarriers: intracellular distribution of cationic liposomes of different composition.
Article in Molecular pharmaceutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Raman Spectroscopy Characterization of Multi-Functionalized Liposomes as Drug-Delivery Systems for Neurological Disorders.Nanomaterials (Basel, Switzerland) · 2023Article
- Strategies and Progress of Raman Technologies for Cellular Uptake Analysis of the Drug Delivery Systems.International journal of nanomedicine · 2023Review
- Vibrational Spectroscopy in Assessment of Early Osteoarthritis-A Narrative Review.International journal of molecular sciences · 2021Review
- Coherent Raman Scattering Microscopy in Oncology Pharmacokinetic Research.Frontiers in pharmacology · 2021Review
- Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling.Journal of materials chemistry. B · 2020Article
- Raman Imaging of Nanocarriers for Drug Delivery.Nanomaterials (Basel, Switzerland) · 2019Review
- Label-free Molecular Imaging and Analysis by Raman Spectroscopy.Acta histochemica et cytochemica · 2018Article
- Circulating Lipoproteins: A Trojan Horse Guiding Squalenoylated Drugs to LDL-Accumulating Cancer Cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Article
- Stimulated Raman scattering microscopy: an emerging tool for drug discovery.Chemical Society reviews · 2016Review
- Vibrational spectroscopy and imaging for concurrent cellular trafficking of co-localized doxorubicin and deuterated phospholipid vesicles.Nanoscale · 2016Article
- Dual-functionalized liposomal delivery system for solid tumors based on RGD and a pH-responsive antimicrobial peptide.Scientific reports · 2016Article
- NEXT STEP IN DRUG DELIVERY: GETTING TO INDIVIDUAL ORGANELLES.Drug delivery and translational research · 2012Article
- Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Nanotechnology is playing an increasing role in targeted drug delivery into pathological tissues. Drug-loaded pharmaceutical nanocarriers can be delivered into diseased sites by passive targeting (spontaneous accumulation of nanocarriers in the areas with affected vasculature) or by active targeting (via site-specific ligands attached to the surface of drug-loaded nanocarriers). Subsequent level of targeting requires cellular internalization of nanocarriers and their specific association with certain individual cell organelles. The control over intracellular distribution of pharmaceutical nanocarriers requires effective and noninvasive methods of their visualization inside cells. In an attempt to enhance cellular internalization of pharmaceutical nanocarriers and their association with mitochondria specifically, we have prepared three types of cationic liposomes and investigated their intracellular distribution. The analysis was performed using Raman microspectroscopy in order to provide morphological information as well as biochemical signatures of the sample. It was demonstrated that Raman microscopy allows evaluation of the extent of mitochondrial association depending on the liposome composition.
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Registered trials
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