ArticleJournal of obstetric, gynecologic, and neonatal nursing : JOGNN2012
Opioid dependency in pregnancy and length of stay for neonatal abstinence syndrome.
Article in Journal of obstetric, gynecologic, and neonatal nursing : JOGNN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 6 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Opioid treatment for opioid withdrawal in newborn infants.The Cochrane database of systematic reviews · 2021Pooled it
- Non-pharmacological care for opioid withdrawal in newborns.The Cochrane database of systematic reviews · 2020Pooled it
- Supporting breastfeeding for women on opioid maintenance therapy: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2019Pooled it
- Childhood neurodevelopment after prescription of maintenance methadone for opioid dependency in pregnancy: a systematic review and meta-analysis.Developmental medicine and child neurology · 2019Pooled it
- Guideline
- Review of the assessment and management of neonatal abstinence syndrome.Addiction science & clinical practice · 2014Pooled it
- Randomized Clinical Trial of Standard- Versus High-Calorie Formula for Methadone-Exposed Infants: A Feasibility Study.Hospital pediatrics · 2018Trial
- Disparities and burden of illness among hospitalized cancer patients with opioid dependence.Medical oncology (Northwood, London, England) · 2026Article
- Breastfeeding Intention, Knowledge, and Attitude of Pregnant Women in Treatment for Opioid Use Disorder.American journal of perinatology · 2024Article
- Neonatal Abstinence Syndrome in Infants with Prenatal Exposure to Methadone versus Buprenorphine.Children (Basel, Switzerland) · 2023Article
- Opioid, methamphetamine, and polysubstance use: perinatal outcomes for the mother and infant.Frontiers in pediatrics · 2023Review
- Rooming-in for Infants at Risk for Neonatal Abstinence Syndrome: Outcomes 5 Years following Its Introduction as the Standard of Care at One Hospital.American journal of perinatology · 2022Article
- Economic Evaluation of Interventions for Treatment of Neonatal Opioid Withdrawal Syndrome: A Review.Children (Basel, Switzerland) · 2021Review
- Neonatal Opioid Withdrawal Syndrome (NOWS): A Transgenerational Echo of the Opioid Crisis.Cold Spring Harbor perspectives in medicine · 2021Review
- Single-family room neonatal intensive care unit design: do patient outcomes actually change?Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Neonatal abstinence syndrome management in California birth hospitals: results of a statewide survey.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Maternal responsivity and oxytocin in opioid-dependent mothers.Developmental psychobiology · 2020Article
- Research and policy priorities for addressing prenatal exposure to opioids in Alaska.International journal of circumpolar health · 2019Article
- Differences in hospital length of stay between neonates exposed to buprenorphine versus methadone in utero: A retrospective chart review.Paediatrics & child health · 2019Article
- Neonatal Abstinence Syndrome.Pediatric clinics of North America · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo examine opioid replacement therapy in pregnancy and effect on neonatal outcomes, including length of hospital stay for neonatal abstinence syndrome.
designRetrospective descriptive study.
settingLabor and delivery unit and neonatal intensive care unit (NICU), Eastern Maine Medical Center, Bangor, Maine.
participantsOne hundred fifty-two opioid-dependent pregnant women on methadone maintenance therapy (MMT) (n = 136) or buprenorphine maintenance therapy (BMT) (n = 16) during pregnancy and their neonates. The neonates were born between January 1, 2005 and December 31, 2007.
methodsA review of the electronic medical record (EMR) was conducted of all opioid-dependent women who were maintained on MMT or BMT at the time of admission for labor and delivery and their neonates.
resultsMaternal methadone dose and concomitant in-utero exposure to benzodiazepines prolonged the length of hospital stay for neonates. Length of stay was shorter in breastfed neonates than formula-fed neonates or neonates who received formula and breast milk. Neonates with prenatal exposure to MMT spent more days in the hospital (21 vs. 14 days) for treatment of neonatal abstinence syndrome (NAS) than infants with prenatal exposure to BMT.
conclusionThese findings are consistent with previous research on the simultaneous use of methadone and benzodiazepines during pregnancy and provide further direction for the treatment of opioid dependency during pregnancy. Harm reduction strategies for opioid-dependent pregnant women in substance abuse treatment with MMT may one day include guidance on daily treatment doses and recommendations to avoid the concomitant use of benzodiazepines to lessen NAS. Breastfeeding should be recommended to shorten length of stay. Understanding perinatal and neonatal outcomes of pregnant women on methadone or buprenorphine will help to identify optimal treatment for opioid dependency in pregnancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.