ArticleBMC microbiology2012
Feminizing Wolbachia: a transcriptomics approach with insights on the immune response genes in Armadillidium vulgare.
Article in BMC microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 87 citations in OpenAlex.
- Ovarian transcriptional response to Wolbachia infection in D. melanogaster in the context of between-genotype variation in gene expression.G3 (Bethesda, Md.) · 2023Article
- Conserved organ-specific microbial assemblages in different populations of a terrestrial crab.Frontiers in microbiology · 2023Article
- Restriction ofmBio · 2022Article
- Autophagy Regulates Whitefly-Symbiont Metabolic Interactions.Applied and environmental microbiology · 2022Article
- Cross-Species Comparisons of Nanoparticle Interactions with Innate Immune Systems: A Methodological Review.Nanomaterials (Basel, Switzerland) · 2021Review
- Stressor-Dependant Changes in Immune Parameters in the Terrestrial Isopod Crustacean,Nanomaterials (Basel, Switzerland) · 2021Article
- Population-specific effect ofEcology and evolution · 2020Article
- Microorganisms in the reproductive tissues of arthropods.Nature reviews. Microbiology · 2020Review
- Sex chromosomes control vertical transmission of feminizing Wolbachia symbionts in an isopod.PLoS biology · 2019Article
- Lignocellulose degradation at the holobiont level: teamwork in a keystone soil invertebrate.Microbiome · 2018Article
- Wolbachia Endosymbionts Modify Drosophila Ovary Protein Levels in a Context-Dependent Manner.Applied and environmental microbiology · 2016Article
- The Terrestrial Isopod Microbiome: An All-in-One Toolbox for Animal-Microbe Interactions of Ecological Relevance.Frontiers in microbiology · 2016Review
- The Mutualistic Side of Wolbachia-Isopod Interactions: Wolbachia Mediated Protection Against Pathogenic Intracellular Bacteria.Frontiers in microbiology · 2015Article
- Wolbachia and the insect immune system: what reactive oxygen species can tell us about the mechanisms of Wolbachia-host interactions.Frontiers in microbiology · 2015Review
- Large gene overlaps and tRNA processing in the compact mitochondrial genome of the crustacean Armadillidium vulgare.RNA biology · 2015Article
- Article
- Iron necessity: the secret of Wolbachia's success?PLoS neglected tropical diseases · 2014Review
- Wolbachia is not all about sex: male-feminizing Wolbachia alters the leafhopper Zyginidia pullula transcriptome in a mainly sex-independent manner.Frontiers in microbiology · 2014Article
- Bacterial cell wall synthesis gene uppP is required for Burkholderia colonization of the Stinkbug Gut.Applied and environmental microbiology · 2013Article
- Gene expression in gut symbiotic organ of stinkbug affected by extracellular bacterial symbiont.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWolbachia are vertically transmitted bacteria known to be the most widespread endosymbiont in arthropods. They induce various alterations of the reproduction of their host, including feminization of genetic males in isopod crustaceans. In the pill bug Armadillidium vulgare, the presence of Wolbachia is also associated with detrimental effects on host fertility and lifespan. Deleterious effects have been demonstrated on hemocyte density, phenoloxidase activity, and natural hemolymph septicemia, suggesting that infected individuals could have defective immune capacities. Since nothing is known about the molecular mechanisms involved in Wolbachia-A. vulgare interactions and its secondary immunocompetence modulation, we developed a transcriptomics strategy and compared A. vulgare gene expression between Wolbachia-infected animals (i.e., "symbiotic" animals) and uninfected ones (i.e., "asymbiotic" animals) as well as between animals challenged or not challenged by a pathogenic bacteria.
resultsSince very little genetic data is available on A. vulgare, we produced several EST libraries and generated a total of 28 606 ESTs. Analyses of these ESTs revealed that immune processes were over-represented in most experimental conditions (responses to a symbiont and to a pathogen). Considering canonical crustacean immune pathways, these genes encode antimicrobial peptides or are involved in pathogen recognition, detoxification, and autophagy. By RT-qPCR, we demonstrated a general trend towards gene under-expression in symbiotic whole animals and ovaries whereas the same gene set tends to be over-expressed in symbiotic immune tissues.
conclusionThis study allowed us to generate the first reference transcriptome ever obtained in the Isopoda group and to identify genes involved in the major known crustacean immune pathways encompassing cellular and humoral responses. Expression of immune-related genes revealed a modulation of host immunity when females are infected by Wolbachia, including in ovaries, the crucial tissue for the Wolbachia route of transmission.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.