ArticleScience signaling2012
Diverse sensitivity thresholds in dynamic signaling responses by social amoebae.
Article in Science signaling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Emergent eukaryotic directional sensing via receptor degradation and diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Local negative feedback of Rac activity at the leading edge underlies a pilot pseudopod-like program for amoeboid cell guidance.PLoS biology · 2023Article
- Rate thresholds in cell signaling have functional and phenotypic consequences in non-linear time-dependent environments.Frontiers in cell and developmental biology · 2023Review
- Article
- Three-dimensional stochastic simulation of chemoattractant-mediated excitability in cells.PLoS computational biology · 2021Article
- A rate threshold mechanism regulates MAPK stress signaling and survival.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Migration of Microparticle-Containing Amoeba through Constricted Environments.ACS biomaterials science & engineering · 2020Article
- Regulation of flagellar motor switching by c-di-GMP phosphodiesterases inThe Journal of biological chemistry · 2019Article
- 3DμF - Interactive Design Environment for Continuous Flow Microfluidic Devices.Scientific reports · 2019Article
- Biological signal generators: integrating synthetic biology tools andCurrent opinion in systems biology · 2019Article
- Adaptive information processing of network modules to dynamic and spatial stimuli.BMC systems biology · 2019Article
- Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation.Nature communications · 2018Article
- Minimal Network Topologies for Signal Processing during Collective Cell Chemotaxis.Biophysical journal · 2018Article
- A computational model for how cells choose temporal or spatial sensing during chemotaxis.PLoS computational biology · 2018Article
- Adaptation of Living Systems.Annual review of condensed matter physics · 2018Article
- Structural analyses unravel the molecular mechanism of cyclic di-GMP regulation of bacterial chemotaxis via a PilZ adaptor protein.The Journal of biological chemistry · 2018Article
- The threshold of an excitable system serves as a control mechanism for noise filtering during chemotaxis.PloS one · 2018Article
- Elastic Multi-scale Mechanisms: Computation and Biological Evolution.Journal of molecular evolution · 2018Article
- Cell-to-cell variation sets a tissue-rheology-dependent bound on collective gradient sensing.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
The complex transition from a single-cell to a multicellular life form during the formation of a fruiting body by the amoeba Dictyostelium discoideum is accompanied by a pulsatile collective signaling process that instigates chemotaxis of the constituent cells. Although the cells used for the analysis of this phenomenon are normally genetically identical (isogenic), it is not clear whether they are equally responsive to the waves of the signaling stimulus, nor is it clear how responses across the population influence collective cell behavior. Here, we found that isogenic Dictyostelium cells displayed differing sensitivities to the chemoattractant cyclic adenosine monophosphate (cAMP). Furthermore, the resulting signaling responses could be explained by a model in which cells are refractory to further stimulation for 5 to 6 min after the initial input and the signaling output is amplified, with the amplification threshold varying across the cells in the population. This pathway structure could explain intracellular amplification of the chemoattractant gradient during cell migration. The new model predicts that diverse cell responsiveness can facilitate collective cell behavior, specifically due to the presence of a small number of cells in the population with increased responsiveness that aid in propagating the initial cAMP signaling wave across the cell population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.