ReviewScience signaling2012
Chemoattractant signaling in dictyostelium: adaptation and amplification.
Review in Science signaling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- On the origin of the functional versatility of macrophages.Frontiers in physiology · 2023Article
- Adaptive information processing of network modules to dynamic and spatial stimuli.BMC systems biology · 2019Article
- Adaptation of Living Systems.Annual review of condensed matter physics · 2018Article
- A Model for Direction Sensing in Dictyostelium discoideum: Ras Activity and Symmetry Breaking Driven by a Gβγ-Mediated, Gα2-Ric8 -- Dependent Signal Transduction Network.PLoS computational biology · 2016Article
- Rectified directional sensing in long-range cell migration.Nature communications · 2014Article
- Gradient generation platforms: new directions for an established microfluidic technology.Lab on a chip · 2014Article
- Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration.Molecular biology of the cell · 2014Article
- Unraveling adaptation in eukaryotic pathways: lessons from protocells.PLoS computational biology · 2013Article
- Common dynamical features of sensory adaptation in photoreceptors and olfactory sensory neurons.Scientific reports · 2013Article
- Adaptive molecular networks controlling chemotactic migration: dynamic inputs and selection of the network architecture.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The social amoebae Dictyostelium discoideum has long proved a powerful model organism for studying how cells sense and interpret chemoattractant gradients. Because of the rich behavior observed in its response to chemoattractants, as well as the complex nature of the signaling pathways involved, this research has attracted and benefited from the use of theoretical models. Recent quantitative experiments provide support for a popular model: the local excitation, global inhibition mechanism of gradient sensing. Here, I discuss these findings and suggest some important open problems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.