ArticleThe Journal of biological chemistry2012
Mechanistic insights into RAD51-associated protein 1 (RAD51AP1) action in homologous DNA repair.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Phosphoregulation of RAD51AP1 function in homology-directed repair.bioRxiv : the preprint server for biology · 2025Article
- RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA.Molecular cell · 2022Article
- TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R- to D-loop switch.Molecular cell · 2022Article
- METTL3 antagonizes 5‑FU chemotherapy and confers drug resistance in colorectal carcinoma.International journal of oncology · 2022Article
- The functional role of Pescadillo ribosomal biogenesis factor 1 in cancer.Journal of Cancer · 2022Review
- Strategies for accelerating osteogenesis through nanoparticle-based DNA/mitochondrial damage repair.Theranostics · 2022Article
- RAD51AP1 and RAD54L Can Underpin Two Distinct RAD51-Dependent Routes of DNA Damage RepairFrontiers in cell and developmental biology · 2022Article
- Article
- Identification of hub genes associated with esophageal cancer progression using bioinformatics analysis.Oncology letters · 2020Article
- NUCKS1 promotes RAD54 activity in homologous recombination DNA repair.The Journal of cell biology · 2020Article
- The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair.The Journal of biological chemistry · 2020Article
- Chemical Risk Factors of Primary Liver Cancer: An Update.Hepatic medicine : evidence and research · 2020Review
- DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response.Nature communications · 2019Article
- Functional association between NUCKS1 gene and Parkinson disease: A potential susceptibility biomarker.Bioinformation · 2019Article
- Phase I trial of selenium plus chemotherapy in gynecologic cancers.Gynecologic oncology · 2018Article
- Nonstructural Protein 5A Impairs DNA Damage Repair: Implications for Hepatitis C Virus-Mediated Hepatocarcinogenesis.Journal of virology · 2018Article
- Roles of NUCKS1 in Diseases: Susceptibility, Potential Biomarker, and Regulatory Mechanisms.BioMed research international · 2018Review
- Review
- Non‑infective occupational risk factors for hepatocellular carcinoma: A review (Review).Molecular medicine reports · 2017Review
- S100A11 plays a role in homologous recombination and genome maintenance by influencing the persistence of RAD51 in DNA repair foci.Cell cycle (Georgetown, Tex.) · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Homologous recombination catalyzed by the RAD51 recombinase is essential for maintaining genome integrity upon the induction of DNA double strand breaks and other DNA lesions. By enhancing the recombinase activity of RAD51, RAD51AP1 (RAD51-associated protein 1) serves a key role in homologous recombination-mediated chromosome damage repair. We show here that RAD51AP1 harbors two distinct DNA binding domains that are both needed for maximal protein activity under physiological conditions. We have finely mapped the two DNA binding domains in RAD51AP1 and generated mutant variants that are impaired in either or both of the DNA binding domains. Examination of these mutants reveals that both domains are indispensable for RAD51AP1 function in cells. These and other results illuminate the mechanistic basis of RAD51AP1 action in homologous DNA repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.