ArticleNeurourology and urodynamics2012
Loss of bladder smooth muscle caveolae in the aging bladder.
Article in Neurourology and urodynamics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- PIEZO1-mediated mechanosensation links aging to bladder dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Senolytics prevent caveolar CaAging cell · 2023Article
- Age and metabolic syndrome are associated with unsatisfactory improvement in nocturia after holmium laser enucleation of the prostate.Frontiers in surgery · 2022Article
- Decreased urothelial expression of caveolin 1 and 2 in aging rats showing detrusor overactivity: Potential association with aging bladder.Investigative and clinical urology · 2021Article
- Managing Nocturia in Frail Older Adults.Drugs & aging · 2021Review
- Age attenuates the T-type CaAging cell · 2020Article
- Caveolae as Potential Hijackable Gates in Cell Communication.Frontiers in cell and developmental biology · 2020Review
- Change of Detrusor Contractility in Patients with and without Bladder Outlet Obstruction at Ten or More Years of follow-up.Scientific reports · 2019Article
- Dilemmas in Management of the Geriatric Bladder.Current bladder dysfunction reports · 2019Article
- Comparing complications of urethral stricture across various ages: a retrospective analysis of findings from retrograde urethrogram and voiding cysto-urethrogram over 10 years.BMC medical imaging · 2019Article
- Impact of polypropylene prolapse mesh on vaginal smooth muscle in rhesus macaque.American journal of obstetrics and gynecology · 2019Article
- NF-κB and GATA-Binding Factor 6 Repress Transcription of Caveolins in Bladder Smooth Muscle Hypertrophy.The American journal of pathology · 2019Article
- Muscle cells, nerves, fibroblasts and vessels in the detrusor of the rat urinary bladder.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2019Article
- Caveolin-3 differentially orchestrates cholinergic and serotonergic constriction of murine airways.Scientific reports · 2018Article
- Pathophysiology of the underactive bladder.Investigative and clinical urology · 2017Review
- Interaction of Caveolin-3 and HCN is involved in the pathogenesis of diabetic cystopathy.Scientific reports · 2016Article
- Treatment of Overactive Bladder in the Elderly Female: The Case for Trospium, Oxybutynin, Fesoterodine and Darifenacin.Drugs & aging · 2015Review
- Aging changes agonist induced contractile responses in permeabilized rat bladder.Age (Dordrecht, Netherlands) · 2015Article
- Neurogenic mechanisms in bladder and bowel ageing.Biogerontology · 2015Review
- Contemporary concepts in the aetiopathogenesis of detrusor underactivity.Nature reviews. Urology · 2014Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
aimsCaveolae are specialized regions of the cell membrane that modulate signal transduction and alterations in these structures affect bladder smooth muscle (BSM) contraction. Since bladder dysfunctions are common in the elderly, we evaluated the effect of aging on the morphology of caveolae and caveolin protein expression in BSM.
methodsCaveolar morphology (number, size, and depth) in BSM was determined from electron microscopy images of young (10 weeks), adult (6-month old), and old (12-month old) rat urinary bladders. Changes in expression levels of caveolin proteins with age were investigated by Western blot and immunofluorescence microscopy. Caveolin-3 gene expression was determined by real-time RT-PCR in young and 19-month-old rat bladders.
resultsTwelve-month-old animals exhibited 50% fewer BSM caveolae compared to young (P < 0.01). The area of caveolae was significantly decreased at 6 and 12 months. Despite a decrease in the number of BSM caveolae at 12 months, the expression of caveolin-1 and cavin-1 were unaltered with age. In contrast, caveolin-2 and caveolin-3 protein expression and immunoreactivity were reduced in BSM at 6 and 12 months of age. Caveolin-3 gene expression was also downregulated at 19 months compared to young animals.
conclusionBiological aging significantly decreases BSM caveolae number and morphology with associated selective alteration in caveolin protein expression. Since caveolae are protected membrane regions that regulate signal transduction, age-related alterations in caveolae and caveolin protein expression could alter BSM contractility resulting in bladder dysfunctions of the elderly.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.