ArticleThe Plant cell2012
The signal transducer NPH3 integrates the phototropin1 photosensor with PIN2-based polar auxin transport in Arabidopsis root phototropism.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 131 citations in OpenAlex.
- Arabidopsis ECHIDNA Plays an Important Role in Auxin Regulation of Clathrin-Mediated Trafficking During Root Gravitropism.Plant, cell & environment · 2026Article
- Investigation ofPlant signaling & behavior · 2024Article
- The Role of Light-Regulated Auxin Signaling in Root Development.International journal of molecular sciences · 2023Review
- ATANN3 Is Involved in Extracellular ATP-Regulated Auxin Distribution inPlants (Basel, Switzerland) · 2023Article
- Recent insights into metabolic and signalling events of directional root growth regulation and its implications for sustainable crop production systems.Frontiers in plant science · 2023Review
- Algal Ocelloids and Plant Ocelli.Plants (Basel, Switzerland) · 2022Article
- Optimized synthesis of layered double hydroxide lactate nanosheets and their biological effects on Arabidopsis seedlings.Plant methods · 2022Article
- Lessons Learned from the Studies of Roots Shaded from Direct Root Illumination.International journal of molecular sciences · 2021Review
- Regulation of plant phototropic growth by NPH3/RPT2-like substrate phosphorylation and 14-3-3 binding.Nature communications · 2021Article
- CUL3 E3 ligases in plant development and environmental response.Nature plants · 2021Review
- Bundling up the Role of the Actin Cytoskeleton in Primary Root Growth.Frontiers in plant science · 2021Review
- PIN FORMED 2 Modulates the Transport of Arsenite inPlant communications · 2020Article
- Coordinated Shoot and Root Responses to Light Signaling inPlant communications · 2020Review
- Endosidin 2 accelerates PIN2 endocytosis and disturbs intracellular trafficking of PIN2, PIN3, and PIN4 but not of SYT1.PloS one · 2020Article
- Light and auxin signaling cross-talk programme root development in plants.Journal of biosciences · 2019Review
- Root Tropisms: Investigations on Earth and in Space to Unravel Plant Growth Direction.Frontiers in plant science · 2019Review
- Boron Alleviates Aluminum Toxicity by Promoting Root Alkalization in Transition Zone via Polar Auxin Transport.Plant physiology · 2018Article
- Shining Light on the Function of NPH3/RPT2-Like Proteins in Phototropin Signaling.Plant physiology · 2018Review
- Light Signaling, Root Development, and Plasticity.Plant physiology · 2018Review
- Environmental and Genetic Factors Regulating Localization of the Plant Plasma Membrane HPlant physiology · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Under blue light (BL) illumination, Arabidopsis thaliana roots grow away from the light source, showing a negative phototropic response. However, the mechanism of root phototropism is still unclear. Using a noninvasive microelectrode system, we showed that the BL sensor phototropin1 (phot1), the signal transducer NONPHOTOTROPIC HYPOCOTYL3 (NPH3), and the auxin efflux transporter PIN2 were essential for BL-induced auxin flux in the root apex transition zone. We also found that PIN2-green fluorescent protein (GFP) localized to vacuole-like compartments (VLCs) in dark-grown root epidermal and cortical cells, and phot1/NPH3 mediated a BL-initiated pathway that caused PIN2 redistribution to the plasma membrane. When dark-grown roots were exposed to brefeldin A (BFA), PIN2-GFP remained in VLCs in darkness, and BL caused PIN2-GFP disappearance from VLCs and induced PIN2-GFP-FM4-64 colocalization within enlarged compartments. In the nph3 mutant, both dark and BL BFA treatments caused the disappearance of PIN2-GFP from VLCs. However, in the phot1 mutant, PIN2-GFP remained within VLCs under both dark and BL BFA treatments, suggesting that phot1 and NPH3 play different roles in PIN2 localization. In conclusion, BL-induced root phototropism is based on the phot1/NPH3 signaling pathway, which stimulates the shootward auxin flux by modifying the subcellular targeting of PIN2 in the root apex transition zone.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.