ArticleMolecules (Basel, Switzerland)2012
Flavone enhances dengue virus type-2 (NGC strain) infectivity and replication in vero cells.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Advances in anti-dengue virus properties of Traditional Chinese Medicines.Frontiers in microbiology · 2026Review
- Identification and Characterization of Antiviral Activity of Synthetic Compounds Against Mayaro Virus.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Inhibitory Potential of Chromene Derivatives on Structural and Non-Structural Proteins of Dengue Virus.Viruses · 2022Review
- Stem Cell Therapy in Dengue Virus-Infected BALB/C Mice Improves Hepatic Injury.Frontiers in cell and developmental biology · 2021Article
- Resveratrol affects Zika virus replication in vitro.Scientific reports · 2019Article
- Taraxacum officinale and Urtica dioica extracts inhibit dengue virus serotype 2 replication in vitro.BMC complementary and alternative medicine · 2018Article
- Baicalin from Scutellaria baicalensis blocks respiratory syncytial virus (RSV) infection and reduces inflammatory cell infiltration and lung injury in mice.Scientific reports · 2016Article
- The Effect of Hydrocotyle sibthorpioides Lam. Extracts on In Vitro Dengue Replication.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Baicalin, a metabolite of baicalein with antiviral activity against dengue virus.Scientific reports · 2014Article
- Extract of Scutellaria baicalensis inhibits dengue virus replication.BMC complementary and alternative medicine · 2013Article
- Antiviral activity of baicalein and quercetin against the Japanese encephalitis virus.International journal of molecular sciences · 2012Article
- Novel antiviral activity of baicalein against dengue virus.BMC complementary and alternative medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates the effects of 2-phenyl-1-benzopyran-4-one (flavone) on DENV-2 infectivity in Vero cells. Virus adsorption and attachment and intracellular virus replication were investigated using a foci forming unit assay (FFUA) and quantitative RT-PCR, respectively. Addition of flavone (100 μg/mL) significantly increased the number of DENV-2 foci by 35.66% ± 1.52 and 49.66% ± 2.51 when added during and after virus adsorption to the Vero cells, respectively. The average foci size after 4 days of infection increased by 33% ± 2.11 and 89% ± 2.13. The DENV-2 specific RNA copy number in the flavone-treated infected cells increased by 6.41- and 23.1-fold when compared to the mock-treated infected cells. Flavone (100 μg/mL) did not promote or inhibit Vero cell proliferation. The CC₅₀ value of flavone against Vero cells was 446 µg/mL. These results suggest that flavone might enhance dengue virus replication by acting antagonistically towards flavonoids known to inhibit dengue virus replication.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.