ReviewSub-cellular biochemistry2012
Defining signal transduction by inositol phosphates.
Review in Sub-cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Structural insights into the development of inhibitors for inositol phosphate kinases.FEBS letters · 2026Review
- IP6: From Seeds to Science-A Natural Compound's Path to Clinical Promise.Biomolecules · 2025Review
- Valproate independently activates Snf1, inhibits TORC1, and induces repression of INO1 transcription by increasing nuclear localization of Opi1.Scientific reports · 2025Article
- Pools of Independently Cycling Inositol Phosphates Revealed by Pulse Labeling withJournal of the American Chemical Society · 2025Article
- Proteomics revealed novel functions and drought tolerance of Arabidopsis thaliana protein kinase ATG1.BMC biology · 2025Article
- Natural variation in root exudate composition in the genetically structured Arabidopsis thaliana in the Iberian Peninsula.The New phytologist · 2025Article
- Differences in heat tolerance, water use efficiency and growth among Douglas-fir families and varieties evidenced by GWAS and common garden studies.AoB PLANTS · 2023Article
- Phytate Hydrolysate Differently Modulates the Immune Response of Human Healthy and Cancer Colonocytes to Intestinal Bacteria.Nutrients · 2022Article
- The Inositol Phosphate System-A Coordinator of Metabolic Adaptability.International journal of molecular sciences · 2022Review
- The Genetic Basis of Phosphorus Utilization Efficiency in Plants Provide New Insight into Woody Perennial Plants Improvement.International journal of molecular sciences · 2022Review
- Arabidopsis inositol polyphosphate kinases IPK1 and ITPK1 modulate crosstalk between SA-dependent immunity and phosphate-starvation responses.Plant cell reports · 2022Article
- Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application.Molecules (Basel, Switzerland) · 2020Review
- Plant PHR Transcription Factors: Put on A Map.Genes · 2019Review
- PI signal transduction and ubiquitination respond to dehydration stress in the red seaweed Gloiopeltis furcata under successive tidal cycles.BMC plant biology · 2019Article
- A synthetic cyclitol-nucleoside conjugate polyphosphate is a highly potent second messenger mimic.Chemical science · 2019Article
- Messengers for morphogenesis: inositol polyphosphate signaling and yeast pseudohyphal growth.Current genetics · 2019Review
- Inositol phosphate kinases: Expanding the biological significance of the universal core of the protein kinase fold.Advances in biological regulation · 2019Review
- Functional insights into the infective larval stage of Anisakis simplex s.s., Anisakis pegreffii and their hybrids based on gene expression patterns.BMC genomics · 2018Article
- Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling.Topics in current chemistry (Cham) · 2017Review
- Inositol Polyphosphate Binding Specificity of the Jasmonate Receptor Complex.Plant physiology · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Ins(1,4,5)P(3) is a classical intracellular messenger: stimulus-dependent changes in its levels elicits biological effects through its release of intracellular Ca(2+) stores. The Ins(1,4,5)P(3) response is "switched off" by its metabolism to a range of additional inositol phosphates. These metabolites have themselves come to be collectively described as a signaling "family". The validity of that latter definition is critically examined in this review. That is, we assess the strength of the hypothesis that Ins(1,4,5)P(3) metabolites are themselves "classical" signals. Put another way, what is the evidence that the biological function of a particular inositol phosphate depends upon stimulus dependent changes in its levels? In this assessment, examples of an inositol phosphate acting as a cofactor (i.e. its function is not stimulus-dependent) do not satisfy our signaling criteria. We conclude that Ins(3,4,5,6)P(4) is, to date, the only Ins(1,4,5)P(3) metabolite that has been validated to act as a second messenger.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.