Evidence map›Paper›PMID 22374088›Full record

ReviewSub-cellular biochemistry2012

Phosphoinositides in the mammalian endo-lysosomal network.

Peter J Cullen, Jeremy G Carlton

Open access · greenAbstract readReview
In one paragraph

Review in Sub-cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Characterization of the malaria parasiteMicrobiology spectrum · 2025
    Article
  3. Article
  4. The expanding organelle lipidomes: current knowledge and challenges.Cellular and molecular life sciences : CMLS · 2023
    Review
  5. Protrudin-mediated ER-endosome contact sites promote phagocytosis.Cellular and molecular life sciences : CMLS · 2023
    Article
  6. Article
  7. Article
  8. CaAdvances in experimental medicine and biology · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. eLife · 2017
    Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Peter J CullenHenry Wellcome Integrated Signaling Laboratories, School of Biochemistry, Medical Sciences Building, University of Bristol, BS8 1TD, Bristol, United Kingdom, Pete.Cullen@bris.ac.uk.
Jeremy G Carlton
King's College London · GBUniversity of Bristol · GB

Funding

Biotechnology and Biological Sciences Research CouncilWellcome Trust 089928
6 · The paper itself

Abstract

The endo-lysosomal system is an interconnected tubulo-vesicular network that acts as a sorting station to process and distribute internalised cargo. This network accepts cargoes from both the plasma membrane and the biosynthetic pathway, and directs these cargos either towards the lysosome for degradation, the peri-nuclear recycling endosome for return to the cell surface, or to the trans-Golgi network. These intracellular membranes are variously enriched in different phosphoinositides that help to shape compartmental identity. These lipids act to localise a number of phosphoinositide-binding proteins that function as sorting machineries to regulate endosomal cargo sorting. Herein we discuss regulation of these machineries by phosphoinositides and explore how phosphoinositide-switching contributes toward sorting decisions made at this platform.

Indexed as

AnimalsBiological TransportCell CompartmentationCell MembraneClathrinDynaminsEndosomesEukaryotic CellsLysosomesMammalsPhosphatidylinositolsSorting Nexinstrans-Golgi NetworkTransport VesiclesClathrinDynaminsPhosphatidylinositolsSorting Nexins

Identifiers

PMID22374088
PMCPMC4052210
OpenAlexW1889864283

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.