ArticleNucleic acids research2012
Neisseria conserved protein DMP19 is a DNA mimic protein that prevents DNA binding to a hypothetical nitrogen-response transcription factor.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
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- Protein with negative surface charge distribution, Bnr1, shows characteristics of a DNA-mimic protein and may be involved in the adaptation of Burkholderia cenocepacia.MicrobiologyOpen · 2022Article
- Hypothetical protein FoDbp40 influences the growth and virulence ofFrontiers in microbiology · 2022Article
- Structure and DNA damage-dependent derepression mechanism for the XRE family member DG-DdrO.Nucleic acids research · 2019Article
- Interaction of ArmZ with the DNA-binding domain of MexZ induces expression ofAntimicrobial agents and chemotherapy · 2019Article
- The monomeric form of Neisseria DNA mimic protein DMP19 prevents DNA from binding to the histone-like HU protein.PloS one · 2017Article
- Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase.Nucleic acids research · 2016Article
- Noncanonical DNA-binding mode of repressor and its disassembly by antirepressor.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- De novo design of protein mimics of B-DNA.Molecular bioSystems · 2016Article
- How the Knowledge of Interactions between Meningococcus and the Human Immune System Has Been Used to Prepare Effective Neisseria meningitidis Vaccines.Journal of immunology research · 2015Review
- Crowning proteins: modulating the protein surface properties using crown ethers.Angewandte Chemie (International ed. in English) · 2014Article
- The T4 phage DNA mimic protein Arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS.The Journal of biological chemistry · 2014Article
- Pathogens hijack the epigenome: a new twist on host-pathogen interactions.The American journal of pathology · 2014Review
- Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor.Nucleic acids research · 2014Article
- Neisseria conserved hypothetical protein DMP12 is a DNA mimic that binds to histone-like HU protein.Nucleic acids research · 2013Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA mimic proteins occupy the DNA binding sites of DNA-binding proteins, and prevent these sites from being accessed by DNA. We show here that the Neisseria conserved hypothetical protein DMP19 acts as a DNA mimic. The crystal structure of DMP19 shows a dsDNA-like negative charge distribution on the surface, suggesting that this protein should be added to the short list of known DNA mimic proteins. The crystal structure of another related protein, NHTF (Neisseria hypothetical transcription factor), provides evidence that it is a member of the xenobiotic-response element (XRE) family of transcriptional factors. NHTF binds to a palindromic DNA sequence containing a 5'-TGTNAN(11)TNACA-3' recognition box that controls the expression of an NHTF-related operon in which the conserved nitrogen-response protein [i.e. (Protein-PII) uridylyltransferase] is encoded. The complementary surface charges between DMP19 and NHTF suggest specific charge-charge interaction. In a DNA-binding assay, we found that DMP19 can prevent NHTF from binding to its DNA-binding sites. Finally, we used an in situ gene regulation assay to provide evidence that NHTF is a repressor of its down-stream genes and that DMP19 can neutralize this effect. We therefore conclude that the interaction of DMP19 and NHTF provides a novel gene regulation mechanism in Neisseria spps.
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