ArticleEcotoxicology (London, England)2012
Ecotoxicological effects of ciprofloxacin on freshwater species: data integration and derivation of toxicity thresholds for risk assessment.
Article in Ecotoxicology (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 140 citations in OpenAlex.
- Functional stability despite structural changes in freshwater biofilm communities exposed to an antibiotic and an herbicide - the role of nutrient conditions.FEMS microbiology ecology · 2025Article
- Pollution by antimicrobials and antibiotic resistance genes in East Africa: Occurrence, sources, and potential environmental implications.Toxicology reports · 2025Review
- A Review on Fluoroquinolones' Toxicity to Freshwater Organisms and a Risk Assessment.Journal of xenobiotics · 2024Review
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- Biochemical Marker Assessment of Chronic Carbamazepine Exposure at Environmentally Relevant Concentrations in Juvenile Common Carp (Antioxidants (Basel, Switzerland) · 2022Article
- Peroxymonosulfate activation by Co-doped magnetic MnEnvironmental science and pollution research international · 2022Article
- Long-term ecotoxicological effects of ciprofloxacin in combination with caffeine on the microalgaToxicology reports · 2021Article
- Sensitivity of zebrafish (Danio rerio) embryos to hospital effluent compared to Daphnia magna and Aliivibrio fischeri.Physiological research · 2020Article
- Antibacterials in Aquatic Environment and Their Toxicity to Fish.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Selected Pharmaceuticals in Different Aquatic Compartments: Part II-Toxicity and Environmental Risk Assessment.Molecules (Basel, Switzerland) · 2020Review
- A review of the pharmaceutical exposome in aquatic fauna.Environmental pollution (Barking, Essex : 1987) · 2018Review
- Veterinary pharmaceuticals in aqueous systems and associated effects: an update.Environmental science and pollution research international · 2017Review
- Lethal/sublethal responses of Daphnia magna to acute norfloxacin contamination and changes in phytoplankton-zooplankton interactions induced by this antibiotic.Scientific reports · 2017Article
- Metabolism in anoxic permeable sediments is dominated by eukaryotic dark fermentation.Nature geoscience · 2017Article
- Risk-based prioritization of pharmaceuticals in the natural environment in Iraq.Environmental science and pollution research international · 2016Article
- Ecotoxicological evaluation of propranolol hydrochloride and losartan potassium to Lemna minor L. (1753) individually and in binary mixtures.Ecotoxicology (London, England) · 2015Article
- Simultaneous determination and toxicological assessment of penicillins in different water matrices.Ecotoxicology (London, England) · 2014Article
- Risk assessment of antibiotic residues in different water matrices in India: key issues and challenges.Environmental science and pollution research international · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although antibiotics have been increasingly used and detected in natural samples, their ecotoxicological effects on aquatic wildlife are not yet extensively studied. Considering the environmental threat posed by the biological activity of antibiotics it is quite relevant to assess the resulting impact, especially on sub-lethal endpoints. As such, this study evaluated the effects of ciprofloxacin on Pseudokirchneriella subcapitata and Lemna minor growth, on the survival and reproduction of Daphnia magna and on Gambusia holbrooki survival. The risks associated with ciprofloxacin effects on non-target organisms were quantified through the calculation of the PEC/PNEC ratio. Overall, the toxicity values obtained (at the mg L(-1) level) were higher than the environmental concentrations. P. subcapitata and L. minor were more sensitive under short-term exposures than D. magna and G. holbrooki. No acute toxicity was observed for fish. The chronic assay with D. magna evidenced that long term exposures to lower concentrations of this antibiotic induced impairments on its life-history parameters. Such outcome may pre-empt potential damages on the long-term maintenance of natural populations continuously exposed to the input of antibiotics. Indeed, the PEC/PNEC ratios showed that ciprofloxacin represents a risk for the most sensitive aquatic organisms, since the defined threshold of an acceptable risk was considerably surpassed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.