Evidence map›Paper›PMID 22373868›Full record

ArticleNature cell biology2012

Multiple modes of cytoplasmic dynein regulation.

Richard B Vallee, Richard J McKenney, Kassandra M Ori-McKenney

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed.

  1. Article
  2. Exploration of the interaction between dynein intermediate chain and dynactin p150Protein science : a publication of the Protein Society · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Selective motor activation in organelle transport along axons.Nature reviews. Molecular cell biology · 2022
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. International journal of molecular sciences · 2020
    Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Richard B ValleeDepartment of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA. rv2025@columbia.edu
Richard J McKenney
Kassandra M Ori-McKenney

Funding

Motor Proteins in Brain DevelopmentR01HD040182 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI VALLEE, RICHARD BERT · 2000 to 2016
$4.9M
MOLECULAR GENETICS OF CYTOPLASMIC DYNEINR37GM047434 · NIGMS · WORCESTER FOUNDATION FOR BIOMEDICAL RES · PI VALLEE, RICHARD BERT · 1996 to 2006
$3.5M
MOLECULAR GENETICS OF CYTOPLASMIC DYNEINR01GM047434 · NIGMS · WORCESTER FOUNDATION FOR BIOMEDICAL RES · PI VALLEE, RICHARD BERT · 1992 to 2010
$2.6M
NICHD NIH HHS HD40182NIGMS NIH HHS GM47434
6 · The paper itself

Abstract

In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high- and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.

Indexed as

1-Alkyl-2-acetylglycerophosphocholine EsteraseAnimalsBiological TransportCarrier ProteinsCytoplasmic DyneinsDynactin ComplexHumansMicrotubule-Associated ProteinsModels, BiologicalProtein BindingProtein Multimerization1-Alkyl-2-acetylglycerophosphocholine EsteraseCarrier ProteinsCytoplasmic DyneinsDynactin ComplexDYNC1H1 protein, humanMicrotubule-Associated ProteinsNDEL1 protein, humanPAFAH1B1 protein, human

Identifiers

PMID22373868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.