ArticleDigestive diseases and sciences2012
High-fat diet alters gene expression in the liver and colon: links to increased development of aberrant crypt foci.
Article in Digestive diseases and sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Hangry hairs: intermittent fasting linked to hair loss.Cell research · 2025Article
- Changes in the Fecal Metabolome Accompany an Increase in Aberrant Crypt Foci in the Colon of C57BL/6 Mice Fed with a High-Fat Diet.Biomedicines · 2022Article
- Contributing factors common to COVID‑19 and gastrointestinal cancer.Oncology reports · 2022Review
- Azoxymethane Alters the Plasma Metabolome to a Greater Extent in Mice Fed a High-Fat Diet Compared to an AIN-93 Diet.Metabolites · 2021Article
- Azoxymethane-Induced Colorectal Cancer Mice Treated with a Polyphenol-Rich Apple Extract Show Less Neoplastic Lesions and Signs of Cachexia.Foods (Basel, Switzerland) · 2021Article
- Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota.Frontiers in cellular and infection microbiology · 2020Review
- Differences Between the Intestinal Lumen Microbiota of Aberrant Crypt Foci (ACF)-Bearing and Non-bearing Rats.Digestive diseases and sciences · 2018Article
- Effects of Grape Juice in Superoxide Dismutase and Catalase in Colorectal Cancer Carcinogenesis Induced by AzoxymethaneAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Leptin OB3 peptide suppresses leptin-induced signaling and progression in ovarian cancer cells.Journal of biomedical science · 2017Article
- Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Novel leptin OB3 peptide-induced signaling and progression in thyroid cancers: Comparison with leptin.Oncotarget · 2016Article
- Bardoxolone Methyl Prevents High-Fat Diet-Induced Colon Inflammation in Mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Obesity promotes colonic stem cell expansion during cancer initiation.Cancer letters · 2015Article
- Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation.Cell cycle (Georgetown, Tex.) · 2015Article
- Nutrient-induced intestinal adaption and its effect in obesity.Physiology & behavior · 2014Review
- Risk of colonic cancer is not higher in the obese Lep(ob) mouse model compared to lean littermates.Pathology oncology research : POR · 2013Article
- Linking inflammation to tumorigenesis in a mouse model of high-fat-diet-enhanced colon cancer.Cytokine · 2013Article
- Molecular mechanisms of chemopreventive phytochemicals against gastroenterological cancer development.World journal of gastroenterology · 2013Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is associated with an increased risk of colon cancer. High-fat diets that lead to obesity may be a contributing factor, but the mechanisms are unknown.
aimsThis study examines susceptibility to azoxymethane (AOM)-induced precancerous lesions in mice in response to consumption of either a low or a high-fat diet and associated molecular changes in the liver and colon.
methodsGene markers of xenobiotic metabolism, leptin-regulated inflammatory cytokines and proliferation were assessed in liver and colon in response to high-fat feeding to determine links with increased sensitivity to AOM.
resultsHigh-fat feeding increased development of AOM-induced precancerous lesions and was associated with increased CYP2E1 gene expression in the liver, but not the colon. Leptin receptors and the colon stem cell marker (Lgr5) were down-regulated in the proximal colon, with a corresponding up-regulation of the inflammatory cytokine (IL6) in response to high-fat feeding. Notably in the distal colon, where aberrant crypt foci develop in response to AOM, the proliferative stem cell marker, Lgr5, was significantly up-regulated with high-fat feeding.
conclusionsThe current study provides evidence that high-fat diets can alter regulation of molecular markers of xenobiotic metabolism that may expose the colon to carcinogens, in parallel with activation of β-catenin-regulated targets regulating colon epithelial cells. High-fat diets associated with obesity may alter multiple molecular factors that act synergistically to increase the risk of colon cancer associated with obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.