ArticleThe EMBO journal2012
Highly diverse TCRα chain repertoire of pre-immune CD8⁺ T cells reveals new insights in gene recombination.
Article in The EMBO journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus.eLife · 2024Article
- Methods for Study of Mouse T Cell Receptor α and β Gene Rearrangements.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Predicting recognition between T cell receptors and epitopes with TCRGP.PLoS computational biology · 2021Article
- Article
- Alternative pathway for the development of VNature immunology · 2017Article
- Single-cell TCRseq: paired recovery of entire T-cell alpha and beta chain transcripts in T-cell receptors from single-cell RNAseq.Genome medicine · 2016Article
- αβ T cell receptors as predictors of health and disease.Cellular & molecular immunology · 2015Review
- Duality of the murine CD8 compartment.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Characterization of human αβTCR repertoire and discovery of D-D fusion in TCRβ chains.Protein & cell · 2014Article
- Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'.Immunology · 2013Review
- Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci.Journal of immunology (Baltimore, Md. : 1950) · 2013Review
- CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Highly diverse TCRα chain repertoire of pre-immune CD8⁺ T cells reveals new insights in gene recombination.The EMBO journal · 2012Article
- T cells and their eons-old obsession with MHC.Immunological reviews · 2012Review
- Lower TCR repertoire diversity in Traj18-deficient mice.Nature immunology · 2012Article
- Equal opportunity for all.The EMBO journal · 2012Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the T-cell receptor αδ (TCRαδ) locus harbours large libraries of variable (TRAV) and junctional (TRAJ) gene segments, according to previous studies the TCRα chain repertoire is of limited diversity due to restrictions imposed by sequential coordinate TRAV-TRAJ recombinations. By sequencing tens of millions of TCRα chain transcripts from naive mouse CD8(+) T cells, we observed a hugely diverse repertoire, comprising nearly all possible TRAV-TRAJ combinations. Our findings are not compatible with sequential coordinate gene recombination, but rather with a model in which contraction and DNA looping in the TCRαδ locus provide equal access to TRAV and TRAJ gene segments, similarly to that demonstrated for IgH gene recombination. Generation of the observed highly diverse TCRα chain repertoire necessitates deletion of failed attempts by thymic-positive selection and is essential for the formation of highly diverse TCRαβ repertoires, capable of providing good protective immunity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.