ArticleBMC proceedings2011
Gene-based Higher Criticism methods for large-scale exonic single-nucleotide polymorphism data.
Article in BMC proceedings, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- DNA hypomethylation mediates immune response in pan-cancer.Epigenetics · 2023Article
- Detecting epistasis in human complex traits.Nature reviews. Genetics · 2014Review
- Effect of linkage disequilibrium on the identification of functional variants.Genetic epidemiology · 2011Article
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Authors and funding
2 authors.
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Abstract
In genome-wide association studies, gene-based methods measure potential joint genetic effects of loci within genes and are promising for detecting causative genetic variations. Following recent theoretical research in statistical multiple-hypothesis testing, we propose to adapt the Higher Criticism procedures to develop novel gene-based methods that use the information of linkage disequilibrium for detecting weak and sparse genetic signals. With the large-scale exonic single-nucleotide polymorphism data from Genetic Analysis Workshop 17, we show that the new Higher-Criticism-type gene-based methods have higher statistical power to detect causative genes than the minimal P-value method, ridge regression, and the prototypes of Higher Criticism do.
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Registered trials
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