ArticleBMC proceedings2011
An aggregating U-Test for a genetic association study of quantitative traits.
Article in BMC proceedings, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A method to incorporate prior information into score test for genetic association studies.BMC bioinformatics · 2014Article
- Combined genotype and haplotype tests for region-based association studies.BMC genomics · 2013Article
- Article
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Authors and funding
3 authors.
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Abstract
We propose a novel aggregating U-test for gene-based association analysis. The method considers both rare and common variants. It adaptively searches for potential disease-susceptibility rare variants and collapses them into a single "supervariant." A forward U-test is then used to assess the joint association of the supervariant and other common variants with quantitative traits. Using 200 simulated replicates from the Genetic Analysis Workshop 17 mini-exome data, we compare the performance of the proposed method with that of a commonly used approach, QuTie. We find that our method has an equivalent or greater power than QuTie to detect nine genes that influence the quantitative trait Q1. This new approach provides a powerful tool for detecting both common and rare variants associated with quantitative traits.
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Registered trials
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