ArticleArchives of medical science : AMS2010
Cord blood resistin and adiponectin in term newborns of diabetic mothers.
Article in Archives of medical science : AMS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Is low birth weight associated with lower adiponectin levels? - A systematic review and meta-analysis.PloS one · 2025Pooled it
- Diabetes in pregnancy and infant adiposity: systematic review and meta-analysis.Archives of disease in childhood. Fetal and neonatal edition · 2017Pooled it
- Distinct cord blood C-peptide, adipokine, and lipidomic signatures by in utero HIV exposure.Pediatric research · 2022Article
- Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis.Molecular medicine (Cambridge, Mass.) · 2020Article
- Morphofunctional renal alterations in rats induced by intrauterine hyperglycemic environment.Archives of medical science : AMS · 2016Article
- Prevalence of gestational diabetes mellitus and associated risk factors in Turkish women: the Trabzon GDM Study.Archives of medical science : AMS · 2015Article
- Newborn Adipokines and Birth Outcomes.Paediatric and perinatal epidemiology · 2015Article
- Glucose, insulin, and oxygen interplay in placental hypervascularisation in diabetes mellitus.BioMed research international · 2014Review
- Lipids, blood pressure, kidney - what was new in 2011?Archives of medical science : AMS · 2011Article
- Obesity alters the expression profile of clock genes in peripheral blood mononuclear cells.Archives of medical science : AMS · 2011Article
- Waist circumference, ghrelin and selected adipose tissue-derived adipokines as predictors of insulin resistance in obese patients: preliminary results.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAdipose tissue can release hormones into the blood stream in response to specific extracellular stimuli or changes in metabolic status. Resistin, an adipose-secreted factor, is primarily involved in the modulation of insulin sensitivity and adipocyte differentiation. Adiponectin, an adipocyte-specific hormone with insulin sensitizing, anti-inflammatory and anti-atherogenic effects, is reduced in obesity and type II diabetes. The aim of the study was to assess the influence of maternal pre-existing diabetes on cord blood resistin and adiponectin at birth in relation to neonatal anthropometric parameters and cord blood insulin levels. MATERIAL AND
methodsA total of 60 term newborns were prospectively enrolled and categorized into three groups: 20 were macrosomic infants of pre-gestational diabetic mothers (group I), 20 were non-macrosomic infants of pre-gestational diabetic mothers (group II) and 20 were healthy non-macrosomic infants born to non-diabetic mothers serving as controls (group III). Infants' anthropometric indices were recorded. Cord blood samples for glucose, insulin, resistin and adiponectin assay, together with maternal glycosylated haemoglobin were obtained.
resultsSerum insulin was increased while resistin and adiponectin were significantly decreased in infants of diabetic mothers (IDMs) compared to the control group. Serum glucose, insulin, resistin and adiponectin were comparable in group I and II. Cord serum resistin correlated positively with cord blood glucose in IDMs in both macrosomic and non-macrosomic groups. Cord serum insulin correlated positively with triceps skinfold thickness in all studied neonates. Cord serum resistin and adiponectin showed no correlation with neonatal anthropometric indices. Multiple regression analysis demonstrated that insulin, resistin and adiponectin together were highly correlated with birth weight, with adiponectin as the one responsible for this positive correlation.
conclusionsInfants of diabetic mothers had elevated levels of cord serum insulin and suppressed levels of cord serum resistin and adiponectin, suggesting that the regulation of these metabolic pathways is probably operational before birth. Levels were comparable in both macrosomic and non-macrosomic neonates.
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