Evidence map›Paper›PMID 22371647›Full record

ArticleWorld journal of gastroenterology2012

Amplifications of NCOA3 gene in colorectal cancers in a Chinese population.

Zhi Li, Zheng-Yu Fang, Yi Ding, Wan-Tong Yao, Yang Yang, Zhong-Qing Zhu, Wen Wang, Qin-Xian Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhi LiDepartment of Histology and Embryology, Basic Medical College of Zhengzhou University, Zhengzhou 450001, Henan Province, China.
Zheng-Yu Fang
Yi Ding
Wan-Tong Yao
Yang Yang
Zhong-Qing Zhu
Wen Wang
Qin-Xian Zhang
Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the copy number variation of NACO3 gene in colorectal cancer (CRC) and its correlation with tumor progression.

methodsA total of 142 samples of case-matched CRC tissues and adjacent normal tissues were obtained from patients undergoing bowel resection. Quantitative real-time polymerase chain reaction method was used to investigate the copy number variations of NCOA3 as well as gene expression in the collected tissues.

resultsCopy number gains of NCOA3 were detected in 39 CRC samples (27.5%) and were correlated with tumor progression (χ2 = 6.42, P = 0.0112). Moreover, there was a positive correlation between copy number gain and mRNA over-expression of NCOA3 in CRCs (P = 0.0023). Expression level of NCOA3 mRNA was also enhanced in the CRC samples with unaltered copy numbers (3.85 ± 1.23 vs. 2.71 ± 0.64, P < 0.01).

conclusionSporadic colorectal cancers exhibit different mechanisms of NCOA3 regulation.

Indexed as

DNA Copy Number VariationsGene AmplificationAsian PeopleColorectal NeoplasmsDisease ProgressionGene Expression Regulation, NeoplasticHumansNuclear Receptor Coactivator 3NCOA3 protein, humanNuclear Receptor Coactivator 3Colorectal cancerGene copy numberGene expressionNCOA3Tumor progression

Identifiers

PMID22371647
PMCPMC3286150
OpenAlexW2004550704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.