Evidence map›Paper›PMID 22371637›Full record

ArticleWorld journal of gastroenterology2012

Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases.

Paulo R C Almeida, Francisco V A Ferreira, Cássio C Santos, Francisco D Rocha-Filho, Raul R R P Feitosa, Esther A A Falcão, Belise K Cavada, Roberto C P Lima-Júnior, Ronaldo A Ribeiro

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Paulo R C AlmeidaFaculty of Medicine, Federal University of Ceará, 60.430-350 Fortaleza, Brazil. paulo.almeida@ufc.br
Francisco V A Ferreira
Cássio C Santos
Francisco D Rocha-Filho
Raul R R P Feitosa
Esther A A Falcão
Belise K Cavada
Roberto C P Lima-Júnior
Ronaldo A Ribeiro
Universidade Federal do Ceará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate immunoexpression of cyclooxygenase-2 (COX-2) in primary gastric carcinomas and respective lymph node metastases.

methodsImmunohistochemistry to analyze COX-2 expression was performed on tissue microarray slices obtained from 36 specimens of gastrectomy and satellite lymph nodes from patients with gastric carcinoma.

resultsImmunostaining was seen in most cases, and COX-2 expression was higher in lymph node metastases than in corresponding primary gastric tumors of intestinal, diffuse and mixed carcinomas, with a statistically significant difference in the diffuse histotype (P = 0.0108).

conclusionCOX-2 immunoexpression occurs frequently in primary gastric carcinomas, but higher expression of this enzyme is observed in lymph node metastases of the diffuse histotype.

Indexed as

Cyclooxygenase 2HumansLymphatic MetastasisLymph NodesStomach NeoplasmsCyclooxygenase 2PTGS2 protein, humanCyclooxygenase-2Gastric carcinomaImmunoexpressionLymph node metastasesTissue microarray

Identifiers

PMID22371637
PMCPMC3286140
OpenAlexW2112254650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.