ArticleWorld journal of gastroenterology2012
Effects of resistin-like molecule β over-expression on gastric cancer cells in vitro.
Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Context-dependent roles of resistin-like molecule β in mucosal defense and inflammatory diseases.Frontiers in immunology · 2026Review
- An Updated Review of Resistin and Colorectal Cancer.Cureus · 2024Review
- Investigating resistin like beta (RETNLB) as a tumor promoter for oral squamous cell carcinoma.Head & face medicine · 2021Article
- Helicobacter pylori Infection Facilitates the Expression of Resistin-like Molecule Beta in Gastric Carcinoma and Precursor Lesions.Current medical science · 2020Article
- Deletion of resistin-like molecule-beta attenuates angiotensin II-induced abdominal aortic aneurysm.Oncotarget · 2017Article
- IFN-γ regulates human dental pulp stem cells behavior via NF-κB and MAPK signaling.Scientific reports · 2017Article
- microRNA-558 facilitates the expression of hypoxia-inducible factor 2 alpha through binding to 5'-untranslated region in neuroblastoma.Oncotarget · 2016Article
- Resistin-Like Molecule-β Promotes Invasion and Migration of Gastric Carcinoma Cells.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Resistin promotes the expression of vascular endothelial growth factor in ovary carcinoma cells.International journal of molecular sciences · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effects of resistin-like molecule β (RELMβ) over-expression on the invasion, metastasis and angiogenesis of gastric cancer cells.
methodsHuman RELMβ encoding expression vector was constructed and transfected into the RELMβ lowly-expressed gastric cancer cell lines SGC-7901 and MKN-45. Gene expression was measured by Western blotting, reverse transcription polymerase chain reaction (PCR) and real-time quantitative PCR. Cell proliferation was measured by 2-(4,5-dimethyltriazol-2-yl)-2,5-diphenyl tetrazolium bromide colorimetry, colony formation and 5-ethynyl-20-deoxyuridine incorporation assays. The in vitro migration, invasion and metastasis of cancer cells were measured by cell adhesion assay, scratch assay and matrigel invasion assay. The angiogenic capabilities of cancer cells were measured by tube formation of endothelial cells.
resultsTransfection of RELMβ vector into SGC-7901 and MKN-45 cells resulted in over-expression of RELMβ, which did not influence the cellular proliferation. However, over-expression of RELMβ suppressed the in vitro adhesion, invasion and metastasis of cancer cells, accompanied by decreased expression of matrix metalloproteinase-2 (MMP-2) and MMP-9. Moreover, transfection of RELMβ attenuated the expression of vascular endothelial growth factor and in vitro angiogenic capabilities of cancer cells.
conclusionOver-expression of RELMβ abolishes the invasion, metastasis and angiogenesis of gastric cancer cells in vitro, suggesting its potentials as a novel therapeutic target for gastric cancer.
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