ArticleProceedings of the National Academy of Sciences of the United States of America2012
Trafficking of protein into the recently established photosynthetic organelles of Paulinella chromatophora.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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66 citing papers in PubMed.
- Review
- Plant plastids: from evolutionary origins to functional specialization and organelle interactions.Journal of experimental botany · 2025Review
- The Paulinella chromatophore transit peptide part2 adopts a structural fold similar to the γ-glutamyl-cyclotransferase fold.Plant physiology · 2025Article
- Genomes of nitrogen-fixing eukaryotes reveal an alternate path for organellogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems.Current opinion in chemical biology · 2025Review
- Protein import into bacterial endosymbionts and evolving organelles.The FEBS journal · 2025Review
- A reassessment of the "hard-steps" model for the evolution of intelligent life.Science advances · 2025Review
- Environment-dependent mutualism-parasitism transitions in the incipient symbiosis between Tetrahymena utriculariae and Micractinium tetrahymenae.The ISME journal · 2025Article
- Genetic potential for aerobic respiration and denitrification in globally distributed respiratory endosymbionts.Nature communications · 2024Article
- Evidence of a putative COEnvironmental microbiology reports · 2024Article
- Horizontal gene transfer in eukaryotes: aligning theory with data.Nature reviews. Genetics · 2024Review
- Hypothetical chloroplast reading frame 51 encodes a photosystem I assembly factor in cyanobacteria.The Plant cell · 2024Article
- How do bacterial endosymbionts work with so few genes?PLoS biology · 2024Article
- Mitochondrial genomes revisited: why do different lineages retain different genes?BMC biology · 2024Review
- Article
- DNA-binding and protein structure of nuclear factors likely acting in genetic information processing in theProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Loss of key endosymbiont genes may facilitate early host control of the chromatophore iniScience · 2022Article
- Tracking N-terminal protein processing from the Golgi to the chromatophore of a rhizarian amoeba.Plant physiology · 2022Article
- Retrotransposition facilitated the establishment of a primary plastid in the thecate amoebaProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Hypothesis: Trans-splicing Generates Evolutionary Novelty in the Photosynthetic Amoeba Paulinella.Journal of phycology · 2022Article
6 more citing papers are in PubMed but not listed here.
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Endosymbiotic acquisition of bacteria by a protist, with subsequent evolution of the bacteria into mitochondria and plastids, had a transformative impact on eukaryotic biology. Reconstructing events that created a stable association between endosymbiont and host during the process of organellogenesis--including establishment of regulated protein import into nascent organelles--is difficult because they date back more than 1 billion years. The amoeba Paulinella chromatophora contains nascent photosynthetic organelles of more recent evolutionary origin (∼60 Mya) termed chromatophores (CRs). After the initial endosymbiotic event, the CR genome was reduced to approximately 30% of its presumed original size and more than 30 expressed genes were transferred from the CR to the amoebal nuclear genome. Three transferred genes--psaE, psaK1, and psaK2--encode subunits of photosystem I. Here we report biochemical evidence that PsaE, PsaK1, and PsaK2 are synthesized in the amoeba cytoplasm and traffic into CRs, where they assemble with CR-encoded subunits into photosystem I complexes. Additionally, our data suggest that proteins routed to CRs pass through the Golgi apparatus. Whereas genome reduction and transfer of genes from bacterial to host genome have been reported to occur in other obligate bacterial endosymbioses, this report outlines the import of proteins encoded by such transferred genes into the compartment derived from the bacterial endosymbiont. Our study showcases P. chromatophora as an exceptional model in which to study early events in organellogenesis, and suggests that protein import into bacterial endosymbionts might be a phenomenon much more widespread than currently assumed.
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