ArticleThe Journal of cell biology2012
The rate of change in Ca(2+) concentration controls sperm chemotaxis.
Article in The Journal of cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Per capita sperm metabolism is density dependent.The Journal of experimental biology · 2024Pooled it
- Mendelian Randomization Analysis Reveals Iron as a Potential Contributor to Male Infertility.The world journal of men's health · 2026Article
- Sperm hyperactivation drives a circling-and-wandering swimming behavior.Nature communications · 2026Article
- Identification of the governing equation of stimulus-response data for run-and-tumble dynamics.PLoS computational biology · 2025Article
- Calaxin is a key factor for calcium-dependent waveform control in zebrafish sperm.Life science alliance · 2024Article
- Phytophthora zoospores display klinokinetic behaviour in response to a chemoattractant.PLoS pathogens · 2024Article
- Methods and Measures for Investigating Microscale Motility.Integrative and comparative biology · 2023Review
- On the role of calcium diffusion and its rapid buffering in intraflagellar signaling.European biophysics journal : EBJ · 2023Article
- Using the Culex pipiens sperm proteome to identify elements essential for mosquito reproduction.PloS one · 2023Article
- cAMP and the Fibrous Sheath Protein CABYR (CaInternational journal of molecular sciences · 2022Article
- CatSper and its CaM-like CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Released ATP Mediates Spermatozoa Chemotaxis Promoted by Uterus-Derived Factor (UDF) inInternational journal of molecular sciences · 2022Article
- Emergence and melting of active vortex crystals.Nature communications · 2021Article
- In Silico Reconstruction of Sperm Chemotaxis.International journal of molecular sciences · 2021Article
- Reconstruction of the three-dimensional beat pattern underlying swimming behaviors of sperm.The European physical journal. E, Soft matter · 2021Article
- Flagellar kinematics reveals the role of environment in shaping sperm motility.Journal of the Royal Society, Interface · 2020Article
- Article
- Modular analysis of the control of flagellar Ca2+-spike trains produced by CatSper and CaV channels in sea urchin sperm.PLoS computational biology · 2020Article
- Neuronal coordination of motile cilia in locomotion and feeding.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- The steering gaits of sperm.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During chemotaxis and phototaxis, sperm, algae, marine zooplankton, and other microswimmers move on helical paths or drifting circles by rhythmically bending cell protrusions called motile cilia or flagella. Sperm of marine invertebrates navigate in a chemoattractant gradient by adjusting the flagellar waveform and, thereby, the swimming path. The waveform is periodically modulated by Ca(2+) oscillations. How Ca(2+) signals elicit steering responses and shape the path is unknown. We unveil the signal transfer between the changes in intracellular Ca(2+) concentration ([Ca(2+)](i)) and path curvature (κ). We show that κ is modulated by the time derivative d[Ca(2+)](i)/dt rather than the absolute [Ca(2+)](i). Furthermore, simulation of swimming paths using various Ca(2+) waveforms reproduces the wealth of swimming paths observed for sperm of marine invertebrates. We propose a cellular mechanism for a chemical differentiator that computes a time derivative. The cytoskeleton of cilia, the axoneme, is highly conserved. Thus, motile ciliated cells in general might use a similar cellular computation to translate changes of [Ca(2+)](i) into motion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.