ArticleThe Journal of physiology2012
In vivo patch-clamp recording from locus coeruleus neurones in the rat brainstem.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Chronic random sleep deprivation causes prolonged pain hypersensitivity via the anterior cingulate cortex.iScience · 2026Article
- What can ANS signals tell us about motor learning? An implication for better assessment of cognitive contribution to motor learning.Frontiers in behavioral neuroscience · 2025Article
- Excess intracellular ATP causes neuropathic pain following spinal cord injury.Cellular and molecular life sciences : CMLS · 2022Article
- Prenatal exposure to morphine enhances excitability in locus coeruleus neurons.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- In Vivo Whole-Cell Patch-Clamp Methods: Recent Technical Progress and Future Perspectives.Sensors (Basel, Switzerland) · 2021Review
- Ascending noradrenergic excitation from the locus coeruleus to the anterior cingulate cortex.Molecular brain · 2020Article
- Mechanisms of decreased cholinergic arousal in focal seizures: In vivo whole-cell recordings from the pedunculopontine tegmental nucleus.Experimental neurology · 2019Article
- Functional Organization of the Sympathetic Pathways Controlling the Pupil: Light-Inhibited and Light-Stimulated Pathways.Frontiers in neurology · 2018Review
- GABAergic ventrolateral pre‑optic nucleus neurons are involved in the mediation of the anesthetic hypnosis induced by propofol.Molecular medicine reports · 2017Article
- Acute inflammation reveals GABAPhysiological reports · 2017Article
- Theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition.Nature communications · 2017Article
- Resolving the Brainstem Contributions to Attentional Analgesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The Modulatory Effect of Acupuncture on the Activity of Locus Coeruleus Neuronal Cells: A Review.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- Retrograde optogenetic characterization of the pontospinal module of the locus coeruleus with a canine adenoviral vector.Brain research · 2016Article
- Coordinated forms of noradrenergic plasticity in the locus coeruleus and primary auditory cortex.Nature neuroscience · 2015Article
- Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.Journal of biomedical science · 2015Article
- Dysfunctional inhibitory mechanisms in locus coeruleus neurons of the wistar kyoto rat.The international journal of neuropsychopharmacology · 2015Article
- Optoactivation of locus ceruleus neurons evokes bidirectional changes in thermal nociception in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- Modulation of physiological reflexes by pain: role of the locus coeruleus.Frontiers in integrative neuroscience · 2012Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Locus coeruleus (LC) neurones extend noradrenergic projections throughout the neuroaxis and are involved in homeostatic functions such as pain modulation, arousal and cardio-respiratory control. To address the cellular mechanisms underlying pain modulation we have developed a patch-clamp recording technique from LC neurones in anaesthetized rats. These recordings showed LC discharge in vivo to be driven by both spontaneous membrane potential oscillations and CNQX-sensitive EPSCs opposed by bicuculine-sensitive IPSCs. Hindlimb pinch evoked a biphasic action potential response underpinned by a slow monophasic excitatory current. This approach allows detailed characterisation of the synaptic and integrative mechanisms of LC responses to naturalistic stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.