ArticleBirth defects research. Part A, Clinical and molecular teratology2012
Is maternal parity an independent risk factor for birth defects?
Article in Birth defects research. Part A, Clinical and molecular teratology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
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- Descriptive and risk factor analysis of infantile cataracts: National Birth Defects Prevention Study, 2000-2011.American journal of medical genetics. Part A · 2022Article
- Epidemiology of Birth Defects in Eastern China and the Associated Risk Factors.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Comparative analysis of perinatal outcomes and birth defects amongst adolescent and older Ugandan mothers: evidence from a hospital-based surveillance database.Reproductive health · 2021Article
- Burden and consequence of birth defects in Nepal-evidence from prospective cohort study.BMC pediatrics · 2021Article
- Risk factors for major external structural birth defects among children in Kiambu County, Kenya: a case-control study.F1000Research · 2021Article
- A multi-country study of prevalence and early childhood mortality among children with omphalocele.Birth defects research · 2020Article
- Maternal risk associated with the VACTERL association: A case-control study.Birth defects research · 2020Article
- Insufficiency of melatonin in follicular fluid is a reversible cause for advanced maternal age-related aneuploidy in oocytes.Redox biology · 2020Article
- Population-based birth defects data in the United States, 2012-2016: A focus on abdominal wall defects.Birth defects research · 2019Article
- Risk estimates of recurrent congenital anomalies in the UK: a population-based register study.BMC medicine · 2017Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAlthough associations between maternal parity and birth defects have been observed previously, few studies have focused on the possibility that parity is an independent risk factor for birth defects. We investigated the relation between levels of parity and a range of birth defects, adjusting each defect group for the same covariates.
methodsWe included infants who had an estimated delivery date between 1997 and 2007 and participated in the National Birth Defects Prevention Study, a multisite case-control study. Cases included infants or fetuses belonging to 38 phenotypes of birth defects (n = 17,908), and controls included infants who were unaffected by a major birth defect (n = 7173). Odds ratios (ORs) were adjusted for 12 covariates using logistic regression.
resultsCompared with primiparous mothers, nulliparous mothers were more likely to have infants with amniotic band sequence, hydrocephaly, esophageal atresia, hypospadias, limb reduction deficiencies, diaphragmatic hernia, omphalocele, gastroschisis, tetralogy of Fallot, and septal cardiac defects, with significant ORs (1.2 to 2.3). Compared with primiparous mothers, multiparous mothers had a significantly increased risk of omphalocele, with an OR of 1.5, but had significantly decreased risk of hypospadias and limb reduction deficiencies, with ORs of 0.77 and 0.77.
conclusionsNulliparity was associated with an increased risk of specific phenotypes of birth defects. Most of the phenotypes associated with nulliparity in this study were consistent with those identified by previous studies. Research into biologic or environmental factors that are associated with nulliparity may be helpful in explaining some or all of these associations.
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