ArticleJournal of clinical immunology2012
Study of the expression of toll-like receptors in different histological types of colorectal polyps and their relationship with colorectal cancer.
Article in Journal of clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Inflammation and Stem Cell Stochasticity of HPV-induced Cervical Cancer: Epigenetics based Biomarkers through Microbiome and Metabolome for Personalized Medicine: A Systematic Review.Current medicinal chemistry · 2025Pooled it
- Nanomaterials modulate tumor-associated macrophages for the treatment of digestive system tumors.Bioactive materials · 2024Review
- Cellular Senescence, Inflammation, and Cancer in the Gastrointestinal Tract.International journal of molecular sciences · 2023Review
- The expression profiles of chemokines, innate immune and apoptotic genes in tumors caused by Rous Sarcoma Virus (RSV-A) in chickens.Genes and immunity · 2022Article
- The Association Between Gut Microbiota, Toll-Like Receptors, and Colorectal Cancer.Clinical Medicine Insights. Oncology · 2022Review
- Efficacy and side effects of immune checkpoint inhibitors in the treatment of colorectal cancer.Therapeutic advances in gastroenterology · 2021Review
- Expression of Main Toll-Like Receptors in Patients with Different Types of Colorectal Polyps and Their Relationship with Gut Microbiota.International journal of molecular sciences · 2020Article
- TLR9 induces colitis-associated colorectal carcinogenesis by regulating NF-κB expression levels.Oncology letters · 2020Article
- The effect of TLR4 on the growth and local inflammatory microenvironment of HPV-related cervical cancer in vivo.Infectious agents and cancer · 2020Article
- Toll-Like Receptor 3 as a Recurrence Risk Factor and a Potential Molecular Therapeutic Target in Colorectal Cancer.Clinical and experimental gastroenterology · 2020Article
- Association of TLR4 and TLR9 polymorphisms and haplotypes with cervical cancer susceptibility.Scientific reports · 2019Article
- Modified FeNanoscale research letters · 2018Article
- Immunotherapy in colorectal cancer: for the select few or all?Journal of gastrointestinal oncology · 2018Review
- TLR9 signaling activation at different stages in colorectal cancer and NF-kappaB expression.OncoTargets and therapy · 2018Article
- The Protective Role of Type I Interferons in the Gastrointestinal Tract.Frontiers in immunology · 2017Review
- The emerging role of immunotherapy in colorectal cancer.Annals of translational medicine · 2016Review
- Decreased expression of TLR7 in gastric cancer tissues and the effects of TLR7 activation on gastric cancer cells.Oncology letters · 2016Article
- Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer.Translational research : the journal of laboratory and clinical medicine · 2016Review
- Toll-like receptor signaling in colorectal cancer: carcinogenesis to cancer therapy.World journal of gastroenterology · 2014Review
- IFNAR1 is a predictor for overall survival in colorectal cancer and its mRNA expression correlated with IRF7 but not TLR9.Medicine · 2014Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDysregulation of toll-like receptors (TLR) signaling can result in chronic inflammatory and over-exuberant repair responses. The aim of this study was to investigate the expression and clinical relevance of TLR in colorectal polyps.
methodsThe expression levels of six TLR were analyzed in 70 patients with different histological types of colorectal polyps, 38 of which developed colorectal carcinoma (CC). These analyses were performed by real-time polymerase chain reaction, western blot, and immunohistochemistry.
resultsTLR9 expression was higher in hyperplastic or adenomatous polyps compared to other polyp types. Hyperplastic polyps also showed increased TLR7 levels compared to the other polyp types. TLR7 expression was lower in both hyperplastic and tubulovillous adenoma polyps from patients who developed CC. TLR9 expression was decreased in hyperplastic and villous polyps from patients who developed CC.
conclusionsOur findings suggest a possible protective role of TLR expression against malignant transformation in the colorectal mucosa. TLR may represent a pathological marker of CC risk in colorectal polyps. The role of these factors in the pathology of colorectal polyps deserves further investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.