ArticleMammalian genome : official journal of the International Mammalian Genome Society2012
Quantitative trait loci for sensitivity to ethanol intoxication in a C57BL/6J×129S1/SvImJ inbred mouse cross.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
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- Adolescent intermittent alcohol exposure produces strain-specific cross-sensitization to nicotine and other behavioral adaptations in adulthood in C57BL/6J and DBA/2J mice.Pharmacology, biochemistry, and behavior · 2023Article
- Interstrain differences in adolescent fear conditioning after acute alcohol exposure.Brain research bulletin · 2023Article
- Genome-wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population.Alcoholism, clinical and experimental research · 2022Article
- Ethanol-Related Behaviors in Mouse Lines Selectively Bred for Drinking to Intoxication.Brain sciences · 2021Article
- Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans.Brain sciences · 2020Review
- Model organism data evolving in support of translational medicine.Lab animal · 2018Review
- Estrogen-Dependent Upregulation ofFrontiers in genetics · 2018Article
- Mouse strain differences in punished ethanol self-administration.Alcohol (Fayetteville, N.Y.) · 2017Article
- The development and biological characteristics of a novel potentially radioresistant inbred mouse strain.Molecular medicine reports · 2017Article
- Sex differences in the behavioral sequelae of chronic ethanol exposure.Alcohol (Fayetteville, N.Y.) · 2017Article
- GeneWeaver: finding consilience in heterogeneous cross-species functional genomics data.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Article
- Effects of ethanol on glycinergic synaptic currents in mouse spinal cord neurons.Journal of neurophysiology · 2014Article
- Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site.Alcoholism, clinical and experimental research · 2013Article
- Social investigation and long-term recognition memory performance in 129S1/SvImJ and C57BL/6JOlaHsd mice and their hybrids.PloS one · 2013Article
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8 authors at 3 institutions in 1 country.
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Abstract
Individual variation in sensitivity to acute ethanol (EtOH) challenge is associated with alcohol drinking and is a predictor of alcohol abuse. Previous studies have shown that the C57BL/6J (B6) and 129S1/SvImJ (S1) inbred mouse strains differ in responses on certain measures of acute EtOH intoxication. To gain insight into genetic factors contributing to these differences, we performed quantitative trait locus (QTL) analysis of measures of EtOH-induced ataxia (accelerating rotarod), hypothermia, and loss of righting reflex (LORR) duration in a B6×S1 F2 population. We confirmed that S1 showed greater EtOH-induced hypothermia (specifically at a high dose) and longer LORR compared to B6. QTL analysis revealed several additive and interacting loci for various phenotypes, as well as examples of genotype interactions with sex. QTLs for different EtOH phenotypes were largely non-overlapping, suggesting separable genetic influences on these behaviors. The most compelling main-effect QTLs were for hypothermia on chromosome 16 and for LORR on chromosomes 4 and 6. Several QTLs overlapped with loci repeatedly linked to EtOH drinking in previous mouse studies. The architecture of the traits we examined was complex but clearly amenable to dissection in future studies. Using integrative genomics strategies, plausible functional and positional candidates may be found. Uncovering candidate genes associated with variation in these phenotypes in this population could ultimately shed light on genetic factors underlying sensitivity to EtOH intoxication and risk for alcoholism in humans.
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