ArticleHaematologica2012
Estradiol increases hematopoietic stem and progenitor cells independent of its actions on bone.
Article in Haematologica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Association between sex hormones and innate cytotoxic capacity of circulating and rectal mucosal immune cells.Clinical immunology communications · 2026Article
- Intersecting Roles of Estrogens and Neutrophils in Modulating Innate Immunity in Cancer.Biomolecules · 2026Review
- Sex-related molecular phenotypes in anxiety-depressive disorders: a machine learning analysis of routine blood biomarkers.Frontiers in psychiatry · 2026Article
- Article
- Influence of donor-recipient sex on engraftment of normal and leukemia stem cells in xenotransplantation.HemaSphere · 2024Article
- Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice.Haematologica · 2021Article
- Advances in preclinical hematopoietic stem cell models and possible implications for improving therapeutic transplantation.Stem cells translational medicine · 2021Review
- Article
- Review
- Comparative Evaluation of Hormones and Hormone-Like Molecule in Lineage Specification of Human Induced Pluripotent Stem Cells.International journal of stem cells · 2019Article
- The Roles of Cholesterol and Its Metabolites in Normal and Malignant Hematopoiesis.Frontiers in endocrinology · 2019Review
- Dynamics of Bone Marrow VSELs and HSCs in Response to Treatment with Gonadotropin and Steroid Hormones, during Pregnancy and Evidence to Support Their Asymmetric/Symmetric Cell Divisions.Stem cell reviews and reports · 2018Article
- Regulation of hematopoietic progenitors by estrogens as a basis for new antileukemic strategies.Molecular & cellular oncology · 2016Article
- Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway.Cell & bioscience · 2016Article
- Estrogen deficiency heterogeneously affects tissue specific stem cells in mice.Scientific reports · 2015Article
- Hormonal regulation of hematopoietic stem cells and their niche: a focus on estrogen.International journal of stem cells · 2015Review
- Estrogen receptors regulate innate immune cells and signaling pathways.Cellular immunology · 2015Review
- Breast cancer stem cells: Multiple capacities in tumor metastasis.Cancer letters · 2014Review
- Girl power: estrogen promotes HSC self-renewal.Cell stem cell · 2014Article
- Stem cells: Sex specificity in the blood.Nature · 2014Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hematopoietic stem and progenitor cells reside in vascular and endosteal niches in the bone marrow. Factors affecting bone remodeling were reported to influence numbers and mobilization of hematopoietic stem cells. We therefore analyzed the effects of estradiol acting anabolic on bone integrity. Here we observe that estradiol increases progenitor cell numbers in the vascular but not in the endosteal compartment independent of its estrogen receptor α-dependent anabolic bone effects. Hematopoietic progenitors capable of reconstituting lethally irradiated mice are increased by enhanced cell cycle entry, leading to a diminished long-term reconstitution potential after serial transplantation. We demonstrate that estradiol action on stromal cells potently favors hematopoietic progenitor/stem cell frequency accompanied by enhanced expression of cell adhesion molecules. Finally, estradiol treatment enhances retention of hematopoietic stem cells in the vascular niche of the bone marrow. We describe for the first time the mechanism of estrogen action on hematopoietic stem and progenitor cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.