Hepatitis B virus, a sex hormone-responsive virus.

Shuping Tong

Abstract readEditorialComment

In one paragraph

Article in Gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed, 1 pooled it

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

The prevalence and clinicopathological features of breast cancer patients with hepatitis B virus infection in China.Oncotarget · 2017
Pooled it
Estrogen and viral infection.Frontiers in immunology · 2025
Review
Testosterone and Estradiol as Novel Prognostic Indicators for HBV-Related Acute-on-Chronic Liver Failure.Frontiers in medicine · 2021
Article
Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection.Frontiers in medicine · 2021
Review
Prediction model of hepatocellular carcinoma risk in Asian patients with chronic hepatitis B treated with entecavir.Oncotarget · 2017
Article
Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma.International journal of endocrinology · 2015
Review
Molecular mechanisms of gender disparity in hepatitis B virus-associated hepatocellular carcinoma.World journal of gastroenterology · 2014
Review
Polymorphism of estrogen receptor alpha (ESR1) is associated with virological response to entecavir (ETV) in nucleoside-naïve adult patients with chronic hepatitis B.Infection · 2013
Article

4 · The record

Corrections and comments

Comment on
Estrogen receptor α represses transcription of HBV genes via interaction with hepatocyte nuclear factor 4α.2012

5 · Who and what money

Authors and funding

1 author.

Shuping Tong

Funding

Hepatitis B virus vaccine escape mutantsR01AI116639 · NIAID · RHODE ISLAND HOSPITAL · PI TONG, SHUPING · 2015 to 2019

$1.8M

Hepatitis B virus immune escape mutantsR21CA133976 · NCI · RHODE ISLAND HOSPITAL · PI TONG, SHUPING · 2008 to 2009

$393k

NCI NIH HHS R21 CA133976NIAID NIH HHS R01 AI116639

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression Regulation, ViralTranscription, GeneticAnimalsEstrogen Receptor alphaFemaleHepatitis B virusHepatocyte Nuclear Factor 4HepatocytesHumansMaleESR1 protein, humanEstrogen Receptor alphaHepatocyte Nuclear Factor 4HNF4A protein, humanHnf4a protein, mouse

Identifiers

PMID22370219

DOI10.1053/j.gastro.2012.02.036

PMCPMC6342015

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.