ArticleEnvironmental health perspectives2012
Aflatoxin exposure may contribute to chronic hepatomegaly in Kenyan school children.
Article in Environmental health perspectives, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Incidence and mortality of acute aflatoxicosis: A systematic review.Environment international · 2025Pooled it
- Human Biomonitoring of Mycotoxins in Blood, Plasma and Serum in Recent Years: A Review.Toxins · 2020Pooled it
- Short-term safety and efficacy of calcium montmorillonite clay (UPSN) in children.The American journal of tropical medicine and hygiene · 2014Trial
- A Cross-Sectional Association Between Serum Aflatoxin and Micronutrient Status Among Children Aged 6-24 Months in Rural Tanzania.Maternal & child nutrition · 2025Article
- Aflatoxin exposure and mortality in acutely ill children: results from the CHAIN network cohort.BMJ global health · 2025Article
- Higher plasma AFB1 concentration is associated with increased risk of HPV 16 and HPV 18 detection and persistence among Ugandan women.Environmental health : a global access science source · 2025Article
- Liver Cirrhosis of Unknown Etiology and Its Predictors in Eastern Ethiopia.Risk management and healthcare policy · 2024Article
- Association of plasma aflatoxin with persistent detection of oncogenic human papillomaviruses in cervical samples from Kenyan women enrolled in a longitudinal study.BMC infectious diseases · 2023Article
- Association of Plasma Aflatoxin With Persistent Detection of Oncogenic Human Papillomaviruses in Cervical Samples From Kenyan Women Enrolled in a Longitudinal Study.Research square · 2023Article
- Aflatoxicosis outbreak and its associated factors in Kiteto, Chemba and Kondoa Districts, Tanzania.PLOS global public health · 2023Article
- Lactic Acid Bacteria from African Fermented Cereal-Based Products: Potential Biological Control Agents for Mycotoxins in Kenya.Journal of toxicology · 2022Review
- Aflatoxin Exposure during Early Life Is Associated with Differential DNA Methylation in Two-Year-Old Gambian Children.International journal of molecular sciences · 2021Article
- Distribution of active ingredients of a commercial aflatoxin biocontrol product in naturally occurring fungal communities across Kenya.Microbial biotechnology · 2021Article
- Assessment of Exposure to Mycotoxins in Spanish Children through the Analysis of Their Levels in Plasma Samples.Toxins · 2021Article
- Evaluation of aflatoxin and fumonisin co-exposure in urine samples from healthy volunteers in northern Mexico.Toxicology reports · 2021Article
- Mycotoxin Occurrence, Exposure and Health Implications in Infants and Young Children in Sub-Saharan Africa: A Review.Foods (Basel, Switzerland) · 2020Review
- Biomonitoring of Aflatoxin BToxins · 2020Article
- Risk assessment of aflatoxins in food.EFSA journal. European Food Safety Authority · 2020Article
- Exposure to Mycotoxin-Mixtures via Breast Milk: An Ultra-Sensitive LC-MS/MS Biomonitoring Approach.Frontiers in chemistry · 2020Article
- Detection and Concentration of Plasma Aflatoxin is Associated with Detection of Oncogenic Human Papillomavirus in Kenyan Women.Open forum infectious diseases · 2019Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundPresentation with a firm type of chronic hepatomegaly of multifactorial etiology is common among school-age children in sub-Saharan Africa.
objectiveAflatoxin is a liver toxin and carcinogen contaminating staple maize food. In this study we examined its role in chronic hepatomegaly.
methodsPlasma samples collected in 2002 and again in 2004 from 218 children attending two schools in neighboring villages were assayed for aflatoxin exposure using the aflatoxin-albumin adduct (AF-alb) biomarker. Data were previously examined for associations among hepatomegaly, malaria, and schistosomiasis.
resultsAF-alb levels were high in children from both schools, but the geometric mean (95% confidence interval) in year 2002 was significantly higher in Matangini [206.5 (175.5, 243.0) pg/mg albumin] than in Yumbuni [73.2 (61.6, 87.0) pg/mg; p < 0.001]. AF-alb levels also were higher in children with firm hepatomegaly [176.6 (129.6, 240.7) pg/mg] than in normal children [79.9 (49.6, 128.7) pg/mg; p = 0.029]. After adjusting for Schistosoma mansoni and Plasmodium infection, we estimated a significant 43% increase in the prevalence of hepatomegaly/hepatosplenomegaly for every natural-log-unit increase in AF-alb. In 2004, AF-alb levels were markedly higher than in 2002 [539.7 (463.3, 628.7) vs. 114.5 (99.7, 131.4) pg/mg; p < 0.001] but with no significant difference between the villages or between hepatomegaly and normal groups [539.7 (436.7, 666.9) vs. 512.6 (297.3, 883.8) pg/mg], possibly because acute exposures during an aflatoxicosis outbreak in 2004 may have masked any potential underlying relationship.
conclusionsExposure to aflatoxin was associated with childhood chronic hepatomegaly in 2002. These preliminary data suggest an additional health risk that may be related to aflatoxin exposure in children, a hypothesis that merits further testing.
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