ArticleBMC evolutionary biology2012
Hsp90 is important for fecundity, longevity, and buffering of cryptic deleterious variation in wild fly populations.
Article in BMC evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 76 citations in OpenAlex.
- Gim3 buffers and potentiates de novo mutations that affect fluconazole susceptibility in yeast.EMBO reports · 2026Article
- HSP90 as an evolutionary capacitor drives adaptive eye size reduction via atonal.Nature communications · 2025Article
- The Hsp90 Molecular Chaperone as a Global Modifier of the Genotype-Phenotype-Fitness Map: An Evolutionary Perspective.Journal of molecular biology · 2024Review
- Genome-Wide Analysis of Heat Shock Protein Family and Identification of Their Functions in Rice Quality and Yield.International journal of molecular sciences · 2024Article
- Mutational robustness and the role of buffer genes in evolvability.The EMBO journal · 2024Review
- Heat Shock Protein Genes Affect the Rapid Cold Hardening Ability of Two Invasive Tephritids.Insects · 2024Article
- Repeat length of C9orf72-associated glycine-alanine polypeptides affects their toxicity.Acta neuropathologica communications · 2023Article
- 60Co-γ Radiation Alters Developmental Stages of Zeugodacus cucurbitae (Diptera: Tephritidae) Through Apoptosis Pathways Gene Expression.Journal of insect science (Online) · 2021Article
- A model and test for coordinated polygenic epistasis in complex traits.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Comparative Transcriptomic Analyses of Antibiotic-Treated and Normally RearedFrontiers in cell and developmental biology · 2021Article
- Spider Mites Singly Infected With EitherFrontiers in microbiology · 2021Article
- Imaginal Disc Growth Factor 6 (Idgf6) Is Involved in Larval and Adult Wing Development inFrontiers in genetics · 2020Article
- Genomic divergence and adaptive convergence inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- A transcriptional and functional analysis of heat hardening in two invasive fruit fly species,Evolutionary applications · 2019Article
- It's not magic - Hsp90 and its effects on genetic and epigenetic variation.Seminars in cell & developmental biology · 2019Review
- Imaginal disc growth factor 4 regulates development and temperature adaptation in Bactrocera dorsalis.Scientific reports · 2019Article
- Systemic signalling and local effectors in developmental stability, body symmetry, and size.Cell stress · 2018Review
- Analysis of Epistasis in Natural Traits Using Model Organisms.Trends in genetics : TIG · 2018Review
- Chaperones, Canalization, and Evolution of Animal Forms.International journal of molecular sciences · 2018Review
- A sibling method for identifying vQTLs.PloS one · 2018Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the laboratory, the Drosophila melanogaster heat shock protein Hsp90 can buffer the phenotypic effects of genetic variation. Laboratory experiments either manipulate Hsp90 activity pharmacologically, or they induce mutations with strong effects in the gene Hsp83, the single-copy fly gene encoding Hsp90. It is unknown whether observations from such laboratory experiments are relevant in the wild.
resultsWe here study naturally occurring mutations in Hsp83, and their effects on fitness and phenotypic buffering in flies derived from wild populations. We examined more than 4500 flies from 42 Drosophila populations distributed world-wide for insertions or deletions of mobile DNA in or near the Hsp83 gene. The insertions we observed occur at low population frequencies, and reduce Hsp83 gene expression. In competition experiments, mutant flies performed much more poorly than wild-type flies. Mutant flies were also significantly less fecund and shorter-lived than wild-type flies, as well as less well buffered against cryptic deleterious variation, as we show through inbreeding experiments. Specifically, in Hsp83 mutant flies female fecundity dropped to much lower levels after inbreeding than in wild-type flies. At even slightly elevated temperatures, inbred mutant Hsp83 populations went extinct, whereas inbred wild-type populations persisted.
conclusionsOur work shows that Hsp90, a regulator of the stress response and of signaling, helps buffer deleterious variation in fruit flies derived from wild population, and that its buffering role becomes even more important under heat stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.