ArticleScientific reports2012
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Cannabinoid receptor activation acutely increases synaptic vesicle numbers by activating synapsins in human synapses.Molecular psychiatry · 2021Article
- Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses.Nature communications · 2021Article
- Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease.Biomolecules · 2020Review
- Development and Validation of CRISPR Activator Systems for Overexpression of CB1 Receptors in Neurons.Frontiers in molecular neuroscience · 2020Article
- Cannabinoids: A New Perspective on Epileptogenesis and Seizure Treatment in Early Life in Basic and Clinical Studies.Frontiers in behavioral neuroscience · 2020Article
- Emerging Mechanisms Underlying Dynamics of GABAergic Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Activity-dependent upregulation of presynaptic kainate receptors at immature CA3-CA1 synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice.Hippocampus · 2014Article
- Mixed neurotransmission in the hippocampal mossy fibers.Frontiers in cellular neuroscience · 2013Review
- CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Fluoxetine impairs GABAergic signaling in hippocampal slices from neonatal rats.Frontiers in cellular neuroscience · 2013Article
- Endocannabinoid signaling and synaptic function.Neuron · 2012Review
- Retrograde Suppression of Post-Tetanic Potentiation at the Mossy Fiber-CA3 Pyramidal Cell Synapse.eNeuroArticle
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early in postnatal life, mossy fibres (MF), the axons of granule cells in the dentate gyrus, release GABA which is depolarizing and excitatory. Synaptic currents undergo spike-time dependent long-term depression (STD-LTD) regardless of the temporal order of stimulation (pre versus post and viceversa). Here we show that at P3 but not at P21, STD-LTD, induced by negative pairing, is mediated by endocannabinoids mobilized from the postsynaptic cell during spiking-induced membrane depolarization. By diffusing backward, endocannabinoids activate cannabinoid type-1 (CB1) receptors probably expressed on MF. Thus, STD-LTD was prevented by CB1 receptor antagonists and was absent in CB1-KO mice. Consistent with these data, in situ hybridization experiments revealed detectable level of CB1 mRNA in the granule cell layer at P3 but not at P21. These results indicate that CB1 receptors are transiently expressed on immature MF terminals where they counteract the enhanced neuronal excitability induced by the excitatory action of GABA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.