ArticleObesity research & clinical practice2012
Dysmetabolic Signals in "Metabolically Healthy" Obesity.
Article in Obesity research & clinical practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- Review
- Metabolically Healthy Obesity-Heterogeneity in Definitions and Unconventional Factors.Metabolites · 2020Review
- Higher Appendicular Skeletal Muscle Mass Protects Metabolically Healthy Obese Boys but Not Girls from Cardiometabolic Abnormality.International journal of environmental research and public health · 2019Article
- Factors associated with metabolically healthy status in obesity, overweight, and normal weight at baseline of ELSA-Brasil.Medicine · 2016Article
- Metabolism rather than obesity is associated with ischemic stroke: a cross-sectional study in rural Northeastern China.SpringerPlus · 2016Article
- Metabolically Healthy Obesity Is Not Associated with Food Intake in White or Black Men.The Journal of nutrition · 2015Article
- Food intake does not differ between obese women who are metabolically healthy or abnormal.The Journal of nutrition · 2014Article
- Utility of obesity indicators for metabolically healthy obesity: an observational study using the Korean National Health and Nutrition Examination Survey (2009-2010).BMC public health · 2014Observational
- Metabolically healthy obesity--does it exist?Current atherosclerosis reports · 2014Review
- Metabolically healthy obesity: definitions, determinants and clinical implications.Reviews in endocrine & metabolic disorders · 2013Review
- Article
- Quercetin Preserves β -Cell Mass and Function in Fructose-Induced Hyperinsulinemia through Modulating Pancreatic Akt/FoxO1 Activation.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- All-cause mortality risk of metabolically healthy obese individuals in NHANES III.Journal of obesity · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundObesity is associated with decreased insulin sensitivity, atherogenic dyslipidemia and hypertension, but clinical studies have also identified a "metabolically healthy" obese phenotype.
objectiveTo compare the characteristics of so-called "metabolically healthy" obese (MHO), normal weight subjects (MHNW) and obese with insulin resistance in a nationally representative sample in the United States. DESIGN, SETTING AND
participantsInsulin resistance was defined by a homeostatic model assessment (HOMA) value in the upper tertile for the entire NHANES cohort. "Metabolic health" was defined as the absence of diabetes, insulin resistance, metabolic syndrome, and lipid-lowering therapy. The study evaluated the 314 MHO, 1173 MHNW and 843 insulin-resistant obese from among the 6485 non-diabetic, nno-pregnant adults aged 20-79 years, who participated to the United States National Health and Nutrition Examination Survey, 1999-2004.
main outcome measuresDemographic, metabolic, nutrition and physical activity features.
resultsMHO and MHNW groups were similar regarding age, and fasting glucose and triglyceride levels. MHO had higher insulin (P<0.0001), insulin resistance as measured with the homeostatic model (p<0.0001), non-HDL cholesterol (P=0.002 in females and P=0.049 in males) and C-reactive protein levels (P<0.0001 in females and P=0.038 in males), and lower high-density lipoprotein cholesterol (HDL) levels (P<0.002). In addition, MHO females had higher low-density lipoprotein (LDL) cholesterol levels (P=0.012) and systolic blood pressure (P=0.02), and lower intake of dietary fiber (P=0.0009) and levels of physical activity (p=0.002). Triglycerides levels were normal in the MHO group.
conclusions"Metabolically healthy" obese people have multiple dysmetabolic changes that may signal increased risk for coronary artery disease.
Identifiers
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Registered trials
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