ArticleThe Australian and New Zealand journal of psychiatry2012
Size and shape of the caudate nucleus in individuals with bipolar affective disorder.
Article in The Australian and New Zealand journal of psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Lithium effects in the frontolimbic circuitry: a systematic review of neuroimaging findings in bipolar disorder.Translational psychiatry · 2026Pooled it
- Chronic Co-administration of Methylphenidate and Fluoxetine Reduces Striatal NMDA Receptor Binding in Adolescent Rats.Neurochemical research · 2026Article
- When practice does not make a perfect - paradoxical learning curve in schizophrenia and bipolar disorder revealed by different serial reaction time task variants.Frontiers in psychiatry · 2023Article
- Neuroanatomical Correlates of Social Intelligence Measured by the Guilford Test.Brain topography · 2021Article
- Lithium treatment impacts nucleus accumbens shape in bipolar disorder.NeuroImage. Clinical · 2020Article
- Effects of social adversity and HIV on subcortical shape and neurocognitive function.Brain imaging and behavior · 2018Article
- Subcortical neuromorphometry in schizophrenia spectrum and bipolar disorders.NeuroImage. Clinical · 2016Article
- Subcortical volumes differentiate Major Depressive Disorder, Bipolar Disorder, and remitted Major Depressive Disorder.Journal of psychiatric research · 2015Article
- All the world's a (clinical) stage: rethinking bipolar disorder from a longitudinal perspective.Molecular psychiatry · 2015Review
- Basal ganglia and thalamic morphology in schizophrenia and bipolar disorder.Psychiatry research · 2014Article
- A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research.The American journal of psychiatry · 2014Review
- Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveThe caudate nucleus (CN) is a crucial component of the ventral striatum, which is part of a prefrontal-striatal-thalamic circuit that is modulated by limbic structures to subserve emotional processing. Bipolar disorder is thought to be underpinned by dysfunctional anterior limbic networks, although MRI studies examining the CN have shown equivocal results. As gross volumetric analyses may not detect subtle regional change, we aimed to clarify the role of the CN in bipolar disorder by undertaking shape analysis to detect regional reductions.
methodsThe CN was manually traced on MRI scans from 27 patients with bipolar-I disorder and 24 matched controls. A non-parametric spherical harmonic shape analysis was undertaken using the SPHARM toolkit.
resultsWhilst the left CN volume was consistently larger in the sample, there was no effect of group or gender or significant interactions between these variables. Volume did not correlate with illness duration or lithium dosage, but was larger in those with a history of psychosis at trend level. However, left caudate shape differed significantly between groups, with deflation in an area along the ventromedial surface (connecting to dorsolateral prefrontal regions) in bipolar patients. Psychotic patients showed increases in the dorsal head and body at trend level overall, in regions connecting to medial and orbitofrontal regions.
conclusionsThese findings suggest that subtle rather than gross structural changes occur in the CN, which may not be detectable by volumetric analysis alone, and reflect alterations in specific frontostriatal circuitry in the disorder.
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