Evidence map›Paper›PMID 22368166›Full record

ReviewSeminars in cardiothoracic and vascular anesthesia2012

Myocardial ischemia reperfusion injury: from basic science to clinical bedside.

Anja Frank, Megan Bonney, Stephanie Bonney, Lindsay Weitzel, Michael Koeppen, Tobias Eckle

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in cardiothoracic and vascular anesthesia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 253 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
253citing papers in PubMed, 7 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

253 citing papers in PubMed, 7 syntheses or guidelines pooled it, 479 citations in OpenAlex.

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193 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Anja FrankUniversity of Colorado Denver, Aurora, CO 80045, USA.
Megan Bonney
Stephanie Bonney
Lindsay Weitzel
Michael Koeppen
Tobias Eckle
University of Colorado Denver · USUniversitätsklinikum Würzburg · DE

Funding

Period in Cardio ProtectionK08HL102267 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DE LA GARZA ECKLE, TOBIAS · 2010 to 2014
$658k
NHLBI NIH HHS K08 HL102267NHLBI NIH HHS K08HL102267
6 · The paper itself

Abstract

Myocardial ischemia reperfusion injury contributes to adverse cardiovascular outcomes after myocardial ischemia, cardiac surgery or circulatory arrest. Primarily, no blood flow to the heart causes an imbalance between oxygen demand and supply, named ischemia (from the Greek isch, restriction; and haema, blood), resulting in damage or dysfunction of the cardiac tissue. Instinctively, early and fast restoration of blood flow has been established to be the treatment of choice to prevent further tissue injury. Indeed, the use of thrombolytic therapy or primary percutaneous coronary intervention is the most effective strategy for reducing the size of a myocardial infarct and improving the clinical outcome. Unfortunately, restoring blood flow to the ischemic myocardium, named reperfusion, can also induce injury. This phenomenon was therefore termed myocardial ischemia reperfusion injury. Subsequent studies in animal models of acute myocardial infarction suggest that myocardial ischemia reperfusion injury accounts for up to 50% of the final size of a myocardial infarct. Consequently, many researchers aim to understand the underlying molecular mechanism of myocardial ischemia reperfusion injury to find therapeutic strategies ultimately reducing the final infarct size. Despite the identification of numerous therapeutic strategies at the bench, many of them are just in the process of being translated to bedside. The current review discusses the most striking basic science findings made during the past decades that are currently under clinical evaluation, with the ultimate goal to treat patients who are suffering from myocardial ischemia reperfusion-associated tissue injury.

Indexed as

AnimalsDisease Models, AnimalFibrinolytic AgentsHumansMyocardial InfarctionMyocardial IschemiaMyocardial Reperfusion InjuryPercutaneous Coronary InterventionFibrinolytic Agents

Identifiers

PMID22368166
PMCPMC3457795
OpenAlexW2121659762

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.