ArticleHippocampus2012
Voltage dependence of subthreshold resonance frequency in layer II of medial entorhinal cortex.
Article in Hippocampus, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Theta Oscillons in Behaving Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Gated transformations from egocentric to allocentric reference frames involving retrosplenial cortex, entorhinal cortex, and hippocampus.Hippocampus · 2023Review
- Tuning Neural Synchronization: The Role of Variable Oscillation Frequencies in Neural Circuits.Frontiers in systems neuroscience · 2022Review
- Membrane Resonance in Pyramidal and GABAergic Neurons of the Mouse Perirhinal Cortex.Frontiers in cellular neuroscience · 2021Article
- The neural circuitry supporting successful spatial navigation despite variable movement speeds.Neuroscience and biobehavioral reviews · 2020Review
- An Analysis of Waves Underlying Grid Cell Firing in the Medial Enthorinal Cortex.Journal of mathematical neuroscience · 2017Article
- Post-Inhibitory Rebound Spikes in Rat Medial Entorhinal Layer II/III Principal Cells: In Vivo, In Vitro, and Computational Modeling Characterization.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Physiological Properties of Neurons in Bat Entorhinal Cortex Exhibit an Inverse Gradient along the Dorsal-Ventral Axis Compared to Entorhinal Neurons in Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Rebound spiking in layer II medial entorhinal cortex stellate cells: Possible mechanism of grid cell function.Neurobiology of learning and memory · 2016Article
- Rebound spiking properties of mouse medial entorhinal cortex neurons in vivo.The European journal of neuroscience · 2015Article
- Current questions on space and time encoding.Hippocampus · 2015Review
- Firing properties of entorhinal cortex neurons and early alterations in an Alzheimer's disease transgenic model.Pflugers Archiv : European journal of physiology · 2014Article
- Neuronal rebound spiking, resonance frequency and theta cycle skipping may contribute to grid cell firing in medial entorhinal cortex.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- Theta rhythm and the encoding and retrieval of space and time.NeuroImage · 2014Review
- The spectro-contextual encoding and retrieval theory of episodic memory.Frontiers in human neuroscience · 2014Article
- Grid cell firing patterns may arise from feedback interaction between intrinsic rebound spiking and transverse traveling waves with multiple heading angles.Frontiers in systems neuroscience · 2014Article
- Nonlinear properties of medial entorhinal cortex neurons reveal frequency selectivity during multi-sinusoidal stimulation.Frontiers in cellular neuroscience · 2014Article
- Article
- Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells.Journal of neurophysiology · 2013Article
- Effects of acetylcholine on neuronal properties in entorhinal cortex.Frontiers in behavioral neuroscience · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The resonance properties of individual neurons in entorhinal cortex (EC) may contribute to their functional properties in awake, behaving rats. Models propose that entorhinal grid cells could arise from shifts in the intrinsic frequency of neurons caused by changes in membrane potential owing to depolarizing input from neurons coding velocity. To test for potential changes in intrinsic frequency, we measured the resonance properties of neurons at different membrane potentials in neurons in medial and lateral EC. In medial entorhinal neurons, the resonant frequency of individual neurons decreased in a linear manner as the membrane potential was depolarized between -70 and -55 mV. At more hyperpolarized membrane potentials, cells asymptotically approached a maximum resonance frequency. Consistent with the previous studies, near resting potential, the cells of the medial EC possessed a decreasing gradient of resonance frequency along the dorsal to ventral axis, and cells of the lateral EC lacked resonant properties, regardless of membrane potential or position along the medial to lateral axis within lateral EC. Application of 10 μM ZD7288, the H-channel blocker, abolished all resonant properties in MEC cells, and resulted in physiological properties very similar to lateral EC cells. These results on resonant properties show a clear change in frequency response with depolarization that could contribute to the generation of grid cell firing properties in the medial EC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.