Evidence map›Paper›PMID 22368035›Full record

Trial reportHippocampus2012

Mnemonic strategy training partially restores hippocampal activity in patients with mild cognitive impairment.

Benjamin M Hampstead, Anthony Y Stringer, Randall F Stilla, Michelle Giddens, K Sathian

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hippocampus, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 6 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 6 syntheses or guidelines pooled it, 150 citations in OpenAlex.

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  10. Training gains and transfer effects after mnemonic strategy training in mild cognitive impairment: A fMRI study.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020
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  11. Mnemonic strategy training increases neocortical activation in healthy older adults and patients with mild cognitive impairment.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020
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  15. Preoperative cognitive intervention reduces cognitive dysfunction in elderly patients after gastrointestinal surgery: a randomized controlled trial.Medical science monitor : international medical journal of experimental and clinical research · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Benjamin M HampsteadRehabilitation R&D Center of Excellence, Research Service Line, Atlanta VAMC, Decatur, Georgia, USA. bhampst@emory.edu
Anthony Y Stringer
Randall F Stilla
Michelle Giddens
K Sathian
Emory University · USAtlanta VA Medical Center · US

Funding

The Emory Alzheimer's Disease CenterP50AG025688 · NIA · EMORY UNIVERSITY · PI LEVEY, ALLAN I · 2005 to 2019
$25.7M
PERCEPTUAL PLASTICITY-BASED NEUROREHABILITATIONK24EY017332 · NEI · EMORY UNIVERSITY · PI SATHIAN, KRISHNANKUTTY · 2006 to 2010
$656k
NEI NIH HHS K24 EY017332NIA NIH HHS 2P50AG025688NIA NIH HHS P50 AG025688
6 · The paper itself

Abstract

Learning and memory deficits typify patients with mild cognitive impairment (MCI) and are generally attributed to medial temporal lobe dysfunction. Although the hippocampus is perhaps the most commonly studied neuroanatomical structure in these patients, there have been few attempts to identify rehabilitative interventions that facilitate its functioning. Here, we present results from a randomized, controlled, single-blind study in which patients with MCI and healthy elderly controls (HEC) were randomized to either three sessions of mnemonic strategy training (MS) or a matched-exposure control group (XP). All participants underwent pre- and posttraining fMRI scanning as they encoded and retrieved object-location associations. For the current report, fMRI analyses were restricted to the hippocampus, as defined anatomically. Before training, MCI patients showed reduced hippocampal activity during both encoding and retrieval, relative to HEC. Following training, the MCI MS group demonstrated increased activity during both encoding and retrieval. There were significant differences between the MCI MS and MCI XP groups during retrieval, especially within the right hippocampus. Thus, MS facilitated hippocampal functioning in a partially restorative manner. We conclude that cognitive rehabilitation techniques may help mitigate hippocampal dysfunction in MCI patients.

Indexed as

AgedAged, 80 and overAgingAssociation LearningCognitive Behavioral TherapyCognitive DysfunctionHippocampusHumansMagnetic Resonance ImagingMemory DisordersNeuropsychological TestsSingle-Blind MethodStatistics, NonparametricTemporal Lobe

Identifiers

PMID22368035
PMCPMC3371321
OpenAlexW1969984646

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.