ArticleJournal of microbiology (Seoul, Korea)2012
Saccharomyces cerevisiae Cmr1 protein preferentially binds to UV-damaged DNA in vitro.
Article in Journal of microbiology (Seoul, Korea), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- An integrated structural model of the DNA damage-responsive H3K4me3 binding WDR76:SPIN1 complex with the nucleosome.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- DNA damage repair proteins across the Tree of Life.iScience · 2023Article
- The role of WDR76 protein in human diseases.Bosnian journal of basic medical sciences · 2021Review
- Histone H4 dosage modulates DNA damage response in the pathogenic yeast Candida glabrata via homologous recombination pathway.PLoS genetics · 2020Article
- Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.Journal of proteome research · 2019Article
- Genome Wide Analysis of WD40 Proteins in Saccharomyces cerevisiae and Their Orthologs in Candida albicans.The protein journal · 2019Article
- Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance.Genes & development · 2016Article
- WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.PloS one · 2016Article
- Recruitment of Saccharomyces cerevisiae Cmr1/Ydl156w to Coding Regions Promotes Transcription Genome Wide.PloS one · 2016Article
- Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control.Nature communications · 2015Article
- Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition.The EMBO journal · 2015Article
- Yeast gene CMR1/YDL156W is consistently co-expressed with genes participating in DNA-metabolic processes in a variety of stringent clustering experiments.Journal of the Royal Society, Interface · 2013Article
- Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.Nature cell biology · 2012Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA metabolic processes such as DNA replication, recombination, and repair are fundamentally important for the maintenance of genome integrity and cell viability. Although a large number of proteins involved in these pathways have been extensively studied, many proteins still remain to be identified. In this study, we isolated DNA-binding proteins from Saccharomyces cerevisiae using DNA-cellulose columns. By analyzing the proteins using mass spectrometry, an uncharacterized protein, Cmr1/YDL156W, was identified. Cmr1 showed sequence homology to human Damaged-DNA binding protein 2 in its C-terminal WD40 repeats. Consistent with this finding, the purified recombinant Cmr1 protein was found to be intrinsically associated with DNA-binding activity and exhibited higher affinity to UV-damaged DNA substrates. Chromatin isolation experiments revealed that Cmr1 localized in both the chromatin and supernatant fractions, and the level of Cmr1 in the chromatin fraction increased when yeast cells were irradiated with UV. These results suggest that Cmr1 may be involved in DNA-damage responses in yeast.
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Registered trials
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